Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice
Mast cells have been suggested to play key roles in adipogenesis. We herein show that the expression of preadipocyte, but not adipocyte, marker genes increases in the white adipose tissue of mast cell-deficient (KitW-sh/W-sh) mice under both obese and non-obese conditions. In vitro culturing with ad...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211546313000715 |
| _version_ | 1818910533959548928 |
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| author | Yasushi Ishijima Shin’ya Ohmori Kinuko Ohneda |
| author_facet | Yasushi Ishijima Shin’ya Ohmori Kinuko Ohneda |
| author_sort | Yasushi Ishijima |
| collection | DOAJ |
| description | Mast cells have been suggested to play key roles in adipogenesis. We herein show that the expression of preadipocyte, but not adipocyte, marker genes increases in the white adipose tissue of mast cell-deficient (KitW-sh/W-sh) mice under both obese and non-obese conditions. In vitro culturing with adipogenic factors revealed increased adipocytes differentiated from the KitW-sh/W-sh stromal vascular fraction, suggesting the accumulation of preadipocytes. Moreover, the increased expression of preadipocyte genes was restored by mast cell reconstitution in the KitW-sh/W-sh mice. These results suggest positive effects of mast cells on the preadipocyte to adipocyte transition under both physiological and pathological conditions. |
| first_indexed | 2024-12-19T22:44:20Z |
| format | Article |
| id | doaj.art-0a31e2eb32d443069c867d9cc5c30112 |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-12-19T22:44:20Z |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-0a31e2eb32d443069c867d9cc5c301122022-12-21T20:02:59ZengWileyFEBS Open Bio2211-54632014-01-014C182410.1016/j.fob.2013.11.004Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese miceYasushi IshijimaShin’ya OhmoriKinuko OhnedaMast cells have been suggested to play key roles in adipogenesis. We herein show that the expression of preadipocyte, but not adipocyte, marker genes increases in the white adipose tissue of mast cell-deficient (KitW-sh/W-sh) mice under both obese and non-obese conditions. In vitro culturing with adipogenic factors revealed increased adipocytes differentiated from the KitW-sh/W-sh stromal vascular fraction, suggesting the accumulation of preadipocytes. Moreover, the increased expression of preadipocyte genes was restored by mast cell reconstitution in the KitW-sh/W-sh mice. These results suggest positive effects of mast cells on the preadipocyte to adipocyte transition under both physiological and pathological conditions.http://www.sciencedirect.com/science/article/pii/S2211546313000715Mast cellWhite adipose tissueAdipogenesisObesity |
| spellingShingle | Yasushi Ishijima Shin’ya Ohmori Kinuko Ohneda Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice FEBS Open Bio Mast cell White adipose tissue Adipogenesis Obesity |
| title | Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice |
| title_full | Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice |
| title_fullStr | Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice |
| title_full_unstemmed | Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice |
| title_short | Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice |
| title_sort | mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non obese mice |
| topic | Mast cell White adipose tissue Adipogenesis Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2211546313000715 |
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