Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients

Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients

Notch signaling is activated in the intestinal epithelial cells (IECs) of patients with inflammatory bowel disease (IBD), and contributes to mucosal regeneration. Our previous study indicated that TNF-α and Notch signaling may synergistically promote the expression of the intestinal stem cell (ISC)...

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Bibliographic Details
Main Authors: Reiko Kuno, Go Ito, Ami Kawamoto, Yui Hiraguri, Hady Yuki Sugihara, Sayaka Takeoka, Sayaka Nagata, Junichi Takahashi, Mao Tsuchiya, Sho Anzai, Tomohiro Mizutani, Hiromichi Shimizu, Shiro Yui, Shigeru Oshima, Kiichiro Tsuchiya, Mamoru Watanabe, Ryuichi Okamoto
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Tumour necrosis factor-α (TNF-α)
Notch pathway
OLFM4
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580820302168

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