Methotrexate impaired in-vivo matured mouse oocyte quality and the possible mechanisms

Methotrexate impaired in-vivo matured mouse oocyte quality and the possible mechanisms

Abstract Background Methotrexate (MTX) is an antifolate agent which is widely used in clinic for treating malignancies, rheumatoid arthritis and ectopic pregnancy. As reported, MTX has side effects on gastrointestinal system, nervous system and reproductive system, while its potential damages on ooc...

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Bibliographic Details
Main Authors: Ning Tian, Dan-yu Lv, Ji Yu, Wan-yun Ma
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Molecular and Cell Biology
Subjects:
Methotrexate
Oocyte quality
Folate metabolism
Chromosome
Methylation modification
Online Access:http://link.springer.com/article/10.1186/s12860-020-00298-7

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