Adriamycin-induced, TNF-α-mediated central nervous system toxicity

Adriamycin-induced, TNF-α-mediated central nervous system toxicity

The clinical effectiveness of adriamycin (ADR), a potent chemotherapeutic, is known to be limited by severe cardiotoxic side effects. However, the effect of ADR on brain tissue is not well understood. It is generally thought that ADR is not toxic to the brain because ADR does not pass the blood–brai...

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Bibliographic Details
Main Authors: Jitbanjong Tangpong, Marsha P. Cole, Rukhsana Sultana, Gururaj Joshi, Steven Estus, Mary Vore, William St. Clair, Suvina Ratanachaiyavong, Daret K. St. Clair, D. Allan Butterfield
Format: Article
Language:English
Published: Elsevier 2006-07-01
Series:Neurobiology of Disease
Subjects:
Adriamycin
Tumor necrosis factor alpha
Mitochondrial respiration
p53
Bcl-xL
Central nervous system
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000404

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