Stress Granule-Mediated Oxidized RNA Decay in P-Body: Hypothetical Role of ADAR1, Tudor-SN, and STAU1

Stress Granule-Mediated Oxidized RNA Decay in P-Body: Hypothetical Role of ADAR1, Tudor-SN, and STAU1

Reactive oxygen species (ROS) generated under oxidative stress (OS) cause oxidative damage to RNA. Recent studies have suggested a role for oxidized RNA in several human disorders. Under the conditions of oxidative stress, mRNAs released from polysome dissociation accumulate and initiate stress gran...

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Bibliographic Details
Main Authors: Ravi Kumar Alluri, Zhongwei Li, Keith R. McCrae
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
oxidative stress
stress granules
P-bodies
oxidized RNA
3′ UTR
ADAR1
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.672988/full

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