Visceral adipose tissue and risk of COVID-19 susceptibility, hospitalization, and severity: A Mendelian randomization study
BackgroundCoronavirus Disease 2019 (COVID-19) has rapidly evolved as a global pandemic. Observational studies found that visceral adipose tissue (VAT) increased the likelihood of worse clinical outcomes in COVID-19 patients. Whereas, whether VAT is causally associated with the susceptibility, hospit...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1023935/full |
| _version_ | 1797990556206366720 |
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| author | Lu Chen Xingang Sun Deheng Han Jiawei Zhong Han Zhang Liangrong Zheng |
| author_facet | Lu Chen Xingang Sun Deheng Han Jiawei Zhong Han Zhang Liangrong Zheng |
| author_sort | Lu Chen |
| collection | DOAJ |
| description | BackgroundCoronavirus Disease 2019 (COVID-19) has rapidly evolved as a global pandemic. Observational studies found that visceral adipose tissue (VAT) increased the likelihood of worse clinical outcomes in COVID-19 patients. Whereas, whether VAT is causally associated with the susceptibility, hospitalization, or severity of COVID-19 remains unconfirmed. We aimed to investigate the causal associations between VAT and susceptibility, hospitalization, and severity of COVID-19.MethodsWe applied a two-sample Mendelian randomization (MR) study to infer causal associations between VAT and COVID-19 outcomes. Single-nucleotide polymorphisms significantly associated with VAT were derived from a large-scale genome-wide association study. The random-effects inverse-variance weighted method was used as the main MR approach, complemented by three other MR methods. Additional sensitivity analyses were also performed.ResultsGenetically predicted higher VAT mass was causally associated with higher risks of COVID-19 susceptibility [odds ratios (ORs) = 1.13; 95% confidence interval (CI), 1.09–1.17; P = 4.37 × 10−12], hospitalization (OR = 1.51; 95% CI = 1.38–1.65; P = 4.14 × 10−20), and severity (OR = 1.58; 95% CI = 1.38–1.82; P = 7.34 × 10−11).ConclusionThis study provided genetic evidence that higher VAT mass was causally associated with higher risks of susceptibility, hospitalization, and severity of COVID-19. VAT can be a useful tool for risk assessment in the general population and COVID-19 patients, as well as an important prevention target. |
| first_indexed | 2024-04-11T08:37:18Z |
| format | Article |
| id | doaj.art-0a39d70a21f640ea95ba5a19f5e8e603 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T08:37:18Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-0a39d70a21f640ea95ba5a19f5e8e6032022-12-22T04:34:17ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-10-011010.3389/fpubh.2022.10239351023935Visceral adipose tissue and risk of COVID-19 susceptibility, hospitalization, and severity: A Mendelian randomization studyLu ChenXingang SunDeheng HanJiawei ZhongHan ZhangLiangrong ZhengBackgroundCoronavirus Disease 2019 (COVID-19) has rapidly evolved as a global pandemic. Observational studies found that visceral adipose tissue (VAT) increased the likelihood of worse clinical outcomes in COVID-19 patients. Whereas, whether VAT is causally associated with the susceptibility, hospitalization, or severity of COVID-19 remains unconfirmed. We aimed to investigate the causal associations between VAT and susceptibility, hospitalization, and severity of COVID-19.MethodsWe applied a two-sample Mendelian randomization (MR) study to infer causal associations between VAT and COVID-19 outcomes. Single-nucleotide polymorphisms significantly associated with VAT were derived from a large-scale genome-wide association study. The random-effects inverse-variance weighted method was used as the main MR approach, complemented by three other MR methods. Additional sensitivity analyses were also performed.ResultsGenetically predicted higher VAT mass was causally associated with higher risks of COVID-19 susceptibility [odds ratios (ORs) = 1.13; 95% confidence interval (CI), 1.09–1.17; P = 4.37 × 10−12], hospitalization (OR = 1.51; 95% CI = 1.38–1.65; P = 4.14 × 10−20), and severity (OR = 1.58; 95% CI = 1.38–1.82; P = 7.34 × 10−11).ConclusionThis study provided genetic evidence that higher VAT mass was causally associated with higher risks of susceptibility, hospitalization, and severity of COVID-19. VAT can be a useful tool for risk assessment in the general population and COVID-19 patients, as well as an important prevention target.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1023935/fullCOVID-19visceral adipose tissueMendelian randomizationcausal associationsrisk |
| spellingShingle | Lu Chen Xingang Sun Deheng Han Jiawei Zhong Han Zhang Liangrong Zheng Visceral adipose tissue and risk of COVID-19 susceptibility, hospitalization, and severity: A Mendelian randomization study Frontiers in Public Health COVID-19 visceral adipose tissue Mendelian randomization causal associations risk |
| title | Visceral adipose tissue and risk of COVID-19 susceptibility, hospitalization, and severity: A Mendelian randomization study |
| title_full | Visceral adipose tissue and risk of COVID-19 susceptibility, hospitalization, and severity: A Mendelian randomization study |
| title_fullStr | Visceral adipose tissue and risk of COVID-19 susceptibility, hospitalization, and severity: A Mendelian randomization study |
| title_full_unstemmed | Visceral adipose tissue and risk of COVID-19 susceptibility, hospitalization, and severity: A Mendelian randomization study |
| title_short | Visceral adipose tissue and risk of COVID-19 susceptibility, hospitalization, and severity: A Mendelian randomization study |
| title_sort | visceral adipose tissue and risk of covid 19 susceptibility hospitalization and severity a mendelian randomization study |
| topic | COVID-19 visceral adipose tissue Mendelian randomization causal associations risk |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1023935/full |
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