Predictors of Outcome in Juvenile Myoclonic Epilepsy
Yiqian Chen,1,* Jingzhen Chen,1,* Xingyu Chen,1,* Ru Wang,2 Jianqi Zeng,1 Feng Wang,3 Jiayin Miao1 1Department of Neurology, Zhongshan Hospital, Xiamen University, Xiamen 361004, People’s Republic of China; 2Department of Neurology, Weinan Central Hospital, Weinan 714000, People’...
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| Formato: | Artigo |
| Idioma: | English |
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Dove Medical Press
2020-06-01
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| Colecção: | Risk Management and Healthcare Policy |
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| Acesso em linha: | https://www.dovepress.com/predictors-of-outcome-in-juvenile-myoclonic-epilepsy-peer-reviewed-article-RMHP |
| _version_ | 1828770343414661120 |
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| author | Chen Y Chen J Chen X Wang R Zeng J Wang F Miao J |
| author_facet | Chen Y Chen J Chen X Wang R Zeng J Wang F Miao J |
| author_sort | Chen Y |
| collection | DOAJ |
| description | Yiqian Chen,1,* Jingzhen Chen,1,* Xingyu Chen,1,* Ru Wang,2 Jianqi Zeng,1 Feng Wang,3 Jiayin Miao1 1Department of Neurology, Zhongshan Hospital, Xiamen University, Xiamen 361004, People’s Republic of China; 2Department of Neurology, Weinan Central Hospital, Weinan 714000, People’s Republic of China; 3School of Computer Engineering, Jimei University, Xiamen 361021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiayin MiaoDepartment of Neurology, Zhongshan Hospital, Xiamen University, Xiamen 361004, People’s Republic of ChinaTel +86-15880281527Fax +86 592-2212328Email miaojiayin2006@163.comBackground: Juvenile myoclonic epilepsy (JME) is the most common idiopathic generalized epilepsy syndrome, accounting for 10% of all epilepsy. However, there is limited information regarding the predictors of seizure outcome. The aim of this study was to determine the predictors of seizure outcome in JME patients.Methods: A population-based retrospective study of JME patients who were treated at the Department of Neurology of affiliated Zhongshan Hospital, Xiamen University from 2008 to 2013.Results: Sixty-three patients (30 women and 33 men) were enrolled in this study. The median age at seizure onset was 14 years old, and the average duration of epilepsy was 5 years. The onset of JME at age < 16 years was found in 63.5% of patients. The epileptiform runs ≥ 3 s were observed in 35.8% patients. Febrile seizure was noted in 28.9% of patients. Among 63 patients, 40 patients (63.5%) had remission. Multivariate analysis identified the following factors as significant predictors of seizure outcome: the onset of JME at age < 16 years, epileptiform runs ≥ 3 s runs, and febrile seizure.Conclusion: The onset of JME at age < 16 years, febrile seizures and epileptiform runs ≥ 3 s might be associated with poor long-term seizure outcome in patients with JME.Keywords: juvenile myoclonic epilepsy, seizure, predictor, outcome |
| first_indexed | 2024-12-11T14:04:37Z |
| format | Article |
| id | doaj.art-0a3a1ae6815c48a48b27b9ecdd91fec3 |
| institution | Directory Open Access Journal |
| issn | 1179-1594 |
| language | English |
| last_indexed | 2024-12-11T14:04:37Z |
| publishDate | 2020-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Risk Management and Healthcare Policy |
| spelling | doaj.art-0a3a1ae6815c48a48b27b9ecdd91fec32022-12-22T01:03:42ZengDove Medical PressRisk Management and Healthcare Policy1179-15942020-06-01Volume 1360961354671Predictors of Outcome in Juvenile Myoclonic EpilepsyChen YChen JChen XWang RZeng JWang FMiao JYiqian Chen,1,* Jingzhen Chen,1,* Xingyu Chen,1,* Ru Wang,2 Jianqi Zeng,1 Feng Wang,3 Jiayin Miao1 1Department of Neurology, Zhongshan Hospital, Xiamen University, Xiamen 361004, People’s Republic of China; 2Department of Neurology, Weinan Central Hospital, Weinan 714000, People’s Republic of China; 3School of Computer Engineering, Jimei University, Xiamen 361021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiayin MiaoDepartment of Neurology, Zhongshan Hospital, Xiamen University, Xiamen 361004, People’s Republic of ChinaTel +86-15880281527Fax +86 592-2212328Email miaojiayin2006@163.comBackground: Juvenile myoclonic epilepsy (JME) is the most common idiopathic generalized epilepsy syndrome, accounting for 10% of all epilepsy. However, there is limited information regarding the predictors of seizure outcome. The aim of this study was to determine the predictors of seizure outcome in JME patients.Methods: A population-based retrospective study of JME patients who were treated at the Department of Neurology of affiliated Zhongshan Hospital, Xiamen University from 2008 to 2013.Results: Sixty-three patients (30 women and 33 men) were enrolled in this study. The median age at seizure onset was 14 years old, and the average duration of epilepsy was 5 years. The onset of JME at age < 16 years was found in 63.5% of patients. The epileptiform runs ≥ 3 s were observed in 35.8% patients. Febrile seizure was noted in 28.9% of patients. Among 63 patients, 40 patients (63.5%) had remission. Multivariate analysis identified the following factors as significant predictors of seizure outcome: the onset of JME at age < 16 years, epileptiform runs ≥ 3 s runs, and febrile seizure.Conclusion: The onset of JME at age < 16 years, febrile seizures and epileptiform runs ≥ 3 s might be associated with poor long-term seizure outcome in patients with JME.Keywords: juvenile myoclonic epilepsy, seizure, predictor, outcomehttps://www.dovepress.com/predictors-of-outcome-in-juvenile-myoclonic-epilepsy-peer-reviewed-article-RMHPjuvenile myoclonic epilepsyseizurepredictoroutcome |
| spellingShingle | Chen Y Chen J Chen X Wang R Zeng J Wang F Miao J Predictors of Outcome in Juvenile Myoclonic Epilepsy Risk Management and Healthcare Policy juvenile myoclonic epilepsy seizure predictor outcome |
| title | Predictors of Outcome in Juvenile Myoclonic Epilepsy |
| title_full | Predictors of Outcome in Juvenile Myoclonic Epilepsy |
| title_fullStr | Predictors of Outcome in Juvenile Myoclonic Epilepsy |
| title_full_unstemmed | Predictors of Outcome in Juvenile Myoclonic Epilepsy |
| title_short | Predictors of Outcome in Juvenile Myoclonic Epilepsy |
| title_sort | predictors of outcome in juvenile myoclonic epilepsy |
| topic | juvenile myoclonic epilepsy seizure predictor outcome |
| url | https://www.dovepress.com/predictors-of-outcome-in-juvenile-myoclonic-epilepsy-peer-reviewed-article-RMHP |
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