Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis

Anticoagulant SERPINs: Endogenous Regulators of Hemostasis and Thrombosis

Appropriate activation of coagulation requires a balance between procoagulant and anticoagulant proteins in blood. Loss in this balance leads to hemorrhage and thrombosis. A number of endogenous anticoagulant proteins, such as antithrombin and heparin cofactor II, are members of the serine protease...

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Bibliographic Details
Main Authors: Steven P. Grover, Nigel Mackman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
anticoagulants
coagulation factors
hemostasis
serine protease inhibitors
thrombosis
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.878199/full

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