Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections
Haematological and cytokine alterations in malaria are a broad and controversial subject in the literature. However, few studies have simultaneously evaluated various cytokines in a single patient group during the acute and convalescent phases of infection. The aim of this study was to sequentially...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2014-04-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000200154&lng=en&tlng=en |
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| author | Rodrigo Nunes Rodrigues-da-Silva Josué da Costa Lima-Junior Bruna de Paula Fonseca e Fonseca Paulo Renato Zuquim Antas Arlete Baldez Fabio Luiz Storer Fátima Santos Dalma Maria Banic Joseli de Oliveira-Ferreira |
| author_facet | Rodrigo Nunes Rodrigues-da-Silva Josué da Costa Lima-Junior Bruna de Paula Fonseca e Fonseca Paulo Renato Zuquim Antas Arlete Baldez Fabio Luiz Storer Fátima Santos Dalma Maria Banic Joseli de Oliveira-Ferreira |
| author_sort | Rodrigo Nunes Rodrigues-da-Silva |
| collection | DOAJ |
| description | Haematological and cytokine alterations in malaria are a broad and controversial subject in the literature. However, few studies have simultaneously evaluated various cytokines in a single patient group during the acute and convalescent phases of infection. The aim of this study was to sequentially characterise alterations in haematological patters and circulating plasma cytokine and chemokine levels in patients infected with Plasmodium vivax or Plasmodium falciparum from a Brazilian endemic area during the acute and convalescent phases of infection. During the acute phase, thrombocytopaenia, eosinopaenia, lymphopaenia and an increased number of band cells were observed in the majority of the patients. During the convalescent phase, the haematologic parameters returned to normal. During the acute phase, P. vivax and P. falciparum patients had significantly higher interleukin (IL)-6, IL-8, IL-17, interferon-γ, tumour necrosis factor (TNF)-α, macrophage inflammatory protein-1β and granulocyte-colony stimulating factor levels than controls and maintained high levels during the convalescent phase. IL-10 was detected at high concentrations during the acute phase, but returned to normal levels during the convalescent phase. Plasma IL-10 concentration was positively correlated with parasitaemia in P. vivax and P. falciparum-infected patients. The same was true for the TNF-α concentration in P. falciparum-infected patients. Finally, the haematological and cytokine profiles were similar between uncomplicated P. falciparum and P. vivax infections. |
| first_indexed | 2024-03-12T18:05:03Z |
| format | Article |
| id | doaj.art-0a3ce915cf3e4c25b04d836674eaff5e |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:05:03Z |
| publishDate | 2014-04-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-0a3ce915cf3e4c25b04d836674eaff5e2023-08-02T09:28:31ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602014-04-01109215416210.1590/0074-0276140275S0074-02762014000200154Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infectionsRodrigo Nunes Rodrigues-da-SilvaJosué da Costa Lima-JuniorBruna de Paula Fonseca e FonsecaPaulo Renato Zuquim AntasArlete BaldezFabio Luiz StorerFátima SantosDalma Maria BanicJoseli de Oliveira-FerreiraHaematological and cytokine alterations in malaria are a broad and controversial subject in the literature. However, few studies have simultaneously evaluated various cytokines in a single patient group during the acute and convalescent phases of infection. The aim of this study was to sequentially characterise alterations in haematological patters and circulating plasma cytokine and chemokine levels in patients infected with Plasmodium vivax or Plasmodium falciparum from a Brazilian endemic area during the acute and convalescent phases of infection. During the acute phase, thrombocytopaenia, eosinopaenia, lymphopaenia and an increased number of band cells were observed in the majority of the patients. During the convalescent phase, the haematologic parameters returned to normal. During the acute phase, P. vivax and P. falciparum patients had significantly higher interleukin (IL)-6, IL-8, IL-17, interferon-γ, tumour necrosis factor (TNF)-α, macrophage inflammatory protein-1β and granulocyte-colony stimulating factor levels than controls and maintained high levels during the convalescent phase. IL-10 was detected at high concentrations during the acute phase, but returned to normal levels during the convalescent phase. Plasma IL-10 concentration was positively correlated with parasitaemia in P. vivax and P. falciparum-infected patients. The same was true for the TNF-α concentration in P. falciparum-infected patients. Finally, the haematological and cytokine profiles were similar between uncomplicated P. falciparum and P. vivax infections.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000200154&lng=en&tlng=encytokineschemokinesplateletsP. falciparumP. vivax |
| spellingShingle | Rodrigo Nunes Rodrigues-da-Silva Josué da Costa Lima-Junior Bruna de Paula Fonseca e Fonseca Paulo Renato Zuquim Antas Arlete Baldez Fabio Luiz Storer Fátima Santos Dalma Maria Banic Joseli de Oliveira-Ferreira Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections Memorias do Instituto Oswaldo Cruz cytokines chemokines platelets P. falciparum P. vivax |
| title | Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections |
| title_full | Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections |
| title_fullStr | Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections |
| title_full_unstemmed | Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections |
| title_short | Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections |
| title_sort | alterations in cytokines and haematological parameters during the acute and convalescent phases of plasmodium falciparum and plasmodium vivax infections |
| topic | cytokines chemokines platelets P. falciparum P. vivax |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000200154&lng=en&tlng=en |
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