Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO)
Introduction Very preterm infants are at risk of abnormal microbiome colonisation in the first weeks to months of life. Several important associated factors have been identified including gestational age, mode of delivery, antibiotic exposure and feeding. Preterm infants are at risk of a number of p...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/9/e075060.full |
| _version_ | 1797669351373930496 |
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| author | Eugene M Dempsey Shuo Wang David Healy Catherine Stanton Paul Ross Ghjuvan Grimaud Alicja Katarzyna Warda |
| author_facet | Eugene M Dempsey Shuo Wang David Healy Catherine Stanton Paul Ross Ghjuvan Grimaud Alicja Katarzyna Warda |
| author_sort | Eugene M Dempsey |
| collection | DOAJ |
| description | Introduction Very preterm infants are at risk of abnormal microbiome colonisation in the first weeks to months of life. Several important associated factors have been identified including gestational age, mode of delivery, antibiotic exposure and feeding. Preterm infants are at risk of a number of pathologies for which the microbiome may play a central role, including necrotising enterocolitis and sepsis. The objective of this study is to determine detailed microbiome changes that occur around implementation of different management practices including empiric antibiotic use, advancement of feeds and administration of probiotics during admission to the neonatal intensive care unit.Methods and analysis A single-site, longitudinal observational study of infants born less than 32 weeks gestation, including collection of maternal samples around delivery and breastmilk and infant samples from admission through discharge from the neonatal unit.Ethics and dissemination The protocol was approved by the Clinical Research Ethics Committee of the Cork Teaching Hospitals.The findings from this study will be disseminated in peer-reviewed journals, during scientific conferences, and directly to the study participants. Sequencing data will be deposited in public databases.Trial registration number NCT05803577. |
| first_indexed | 2024-03-11T20:43:01Z |
| format | Article |
| id | doaj.art-0a3f7c52492542e1bf7758554a8c49f2 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-11T20:43:01Z |
| publishDate | 2023-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-0a3f7c52492542e1bf7758554a8c49f22023-10-01T22:15:08ZengBMJ Publishing GroupBMJ Open2044-60552023-09-0113910.1136/bmjopen-2023-075060Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO)Eugene M Dempsey0Shuo Wang1David Healy2Catherine Stanton3Paul Ross4Ghjuvan Grimaud5Alicja Katarzyna Warda6APC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandTeagasc Food Research Centre Moorepark, Moorepark, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandIntroduction Very preterm infants are at risk of abnormal microbiome colonisation in the first weeks to months of life. Several important associated factors have been identified including gestational age, mode of delivery, antibiotic exposure and feeding. Preterm infants are at risk of a number of pathologies for which the microbiome may play a central role, including necrotising enterocolitis and sepsis. The objective of this study is to determine detailed microbiome changes that occur around implementation of different management practices including empiric antibiotic use, advancement of feeds and administration of probiotics during admission to the neonatal intensive care unit.Methods and analysis A single-site, longitudinal observational study of infants born less than 32 weeks gestation, including collection of maternal samples around delivery and breastmilk and infant samples from admission through discharge from the neonatal unit.Ethics and dissemination The protocol was approved by the Clinical Research Ethics Committee of the Cork Teaching Hospitals.The findings from this study will be disseminated in peer-reviewed journals, during scientific conferences, and directly to the study participants. Sequencing data will be deposited in public databases.Trial registration number NCT05803577.https://bmjopen.bmj.com/content/13/9/e075060.full |
| spellingShingle | Eugene M Dempsey Shuo Wang David Healy Catherine Stanton Paul Ross Ghjuvan Grimaud Alicja Katarzyna Warda Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO) BMJ Open |
| title | Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO) |
| title_full | Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO) |
| title_fullStr | Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO) |
| title_full_unstemmed | Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO) |
| title_short | Longitudinal observational study protocol – Preterm Infants: Microbiome Establishment, Neuro-CrossTalk and Origins (PIMENTO) |
| title_sort | longitudinal observational study protocol preterm infants microbiome establishment neuro crosstalk and origins pimento |
| url | https://bmjopen.bmj.com/content/13/9/e075060.full |
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