Operating principles of Notch–Delta–Jagged module of cell–cell communication

Operating principles of Notch–Delta–Jagged module of cell–cell communication

Notch pathway is an evolutionarily conserved cell–cell communication mechanism governing cell-fate during development and tumor progression. It is activated when Notch receptor of one cell binds to either of its ligand—Delta or Jagged—of another cell. Notch–Delta (ND) signaling forms a two-way switc...

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Bibliographic Details
Main Authors: Mohit Kumar Jolly, Marcelo Boareto, Mingyang Lu, Jose’ N Onuchic, Cecilia Clementi, Eshel Ben-Jacob
Format: Article
Language:English
Published: IOP Publishing 2015-01-01
Series:New Journal of Physics
Subjects:
notch signaling
multistability
jagged
sender/receiver
cell–cell communication
pattern formation
Online Access:https://doi.org/10.1088/1367-2630/17/5/055021

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