Toxicoproteomic Profiling of <i>hPXR</i> Transgenic Mice Treated with Rifampicin and Isoniazid

Toxicoproteomic Profiling of <i>hPXR</i> Transgenic Mice Treated with Rifampicin and Isoniazid

Tuberculosis is a global health threat that affects millions of people every year, and treatment-limiting toxicity remains a considerable source of treatment failure. Recent reports have characterized the nature of <i>hPXR</i>-mediated hepatotoxicity and the systemic toxicity of antitube...

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Bibliographic Details
Main Authors: Christopher Trent Brewer, Kiran Kodali, Jing Wu, Timothy I. Shaw, Junmin Peng, Taosheng Chen
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
anemia
antitubercular therapy
cytochrome P450
drug-induced liver injury
heme biosynthesis
hypercoagulability
Online Access:https://www.mdpi.com/2073-4409/9/7/1654

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