Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s disease
BackgroundThe semiology and determinants of apathy are largely unknown across amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Huntington’s disease (HD), due to both motor and non-motor confounders. This study thus aimed at (1) profiling apathy in ALS, PD, and HD and (2) exploring...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1031908/full |
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| author | Barbara Poletti Federica Solca Sabrina Maffi Silvia Torre Laura Carelli Edoardo Nicolò Aiello Edoardo Nicolò Aiello Roberta Ferrucci Roberta Ferrucci Roberta Ferrucci Alberto Priori Alberto Priori Alessia Monti Federico Verde Federico Verde Nicola Ticozzi Nicola Ticozzi Simone Migliore Eugenia Scaricamazza Melissa Casella Ferdinando Squitieri Andrea Ciammola Vincenzo Silani Vincenzo Silani |
| author_facet | Barbara Poletti Federica Solca Sabrina Maffi Silvia Torre Laura Carelli Edoardo Nicolò Aiello Edoardo Nicolò Aiello Roberta Ferrucci Roberta Ferrucci Roberta Ferrucci Alberto Priori Alberto Priori Alessia Monti Federico Verde Federico Verde Nicola Ticozzi Nicola Ticozzi Simone Migliore Eugenia Scaricamazza Melissa Casella Ferdinando Squitieri Andrea Ciammola Vincenzo Silani Vincenzo Silani |
| author_sort | Barbara Poletti |
| collection | DOAJ |
| description | BackgroundThe semiology and determinants of apathy are largely unknown across amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Huntington’s disease (HD), due to both motor and non-motor confounders. This study thus aimed at (1) profiling apathy in ALS, PD, and HD and (2) exploring its clinical determinants.MaterialsConsecutive ALS (N = 99), PD (N = 73), and HD (N = 25) patients underwent a motor-free assessment of apathy (Dimensional Apathy Scale, DAS), global cognition, anxiety and depression. Function was assessed through disease-specific scales. The DAS was also completed by N = 101 healthy controls (HCs). Between-group comparisons on DAS scores were implemented by covarying for all applicable confounders. Predictive models on DAS scores were built through multiple, stepwise regressions.ResultsParkinson’s disease and HD, but not ALS, patients were more apathetic than HCs—with HD patients also selectively showing lower initiation and poorer goal-directed planning than HCs. Higher apathetic features were detected in PD and HD as compared to ALS. Education was a protective factor against apathy in ALS. Anxiety was a risk factor for global apathy in ALS, HD, and to a lesser extent, in PD, whereas, protective only toward affective disintegration in PD and ALS. Cognitive inefficiency was a risk factor toward apathy in both PD and ALS. Depression was a risk factor for executive-related apathy in PD.DiscussionThis study provides unprecedented insights into the heterogeneous semiology and determinants of apathy across ALS, PD, and HD via the DAS, in turn informing clinical practice and research. |
| first_indexed | 2024-04-13T14:54:05Z |
| format | Article |
| id | doaj.art-0a47f712d3c84566a436706d26691bf1 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-13T14:54:05Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-0a47f712d3c84566a436706d26691bf12022-12-22T02:42:30ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652022-11-011410.3389/fnagi.2022.10319081031908Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s diseaseBarbara Poletti0Federica Solca1Sabrina Maffi2Silvia Torre3Laura Carelli4Edoardo Nicolò Aiello5Edoardo Nicolò Aiello6Roberta Ferrucci7Roberta Ferrucci8Roberta Ferrucci9Alberto Priori10Alberto Priori11Alessia Monti12Federico Verde13Federico Verde14Nicola Ticozzi15Nicola Ticozzi16Simone Migliore17Eugenia Scaricamazza18Melissa Casella19Ferdinando Squitieri20Andrea Ciammola21Vincenzo Silani22Vincenzo Silani23Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, ItalyHuntington and Rare Diseases Unit, CSS-Mendel Institute, Fondazione IRCCS Casa Sollievo della Sofferenza Research Hospital, San Giovanni Rotondo, ItalyDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, ItalyPh.D Program in Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, ItalyDepartment of Health Sciences, Aldo Ravelli Center for Neurotechnology and Experimental Brain Therapeutics, International Medical School, University of Milan, Milan, ItalyASST Santi Paolo e Carlo, San Paolo University Hospital, Milan, ItalyIRCCS Ca’ Granda Foundation Maggiore Policlinico Hospital, Milan, ItalyDepartment of Health Sciences, Aldo Ravelli Center for Neurotechnology and Experimental Brain Therapeutics, International Medical School, University of Milan, Milan, ItalyASST Santi Paolo e Carlo, San Paolo University Hospital, Milan, ItalyDepartment of Neurorehabilitation Sciences, Casa di Cura del Policlinico, Milan, ItalyDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Pathophysiology and Transplantation, “Dino Ferrari Center,” Università degli Studi di Milano, Milan, ItalyDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Pathophysiology and Transplantation, “Dino Ferrari Center,” Università degli Studi di Milano, Milan, ItalyHuntington and Rare Diseases Unit, CSS-Mendel Institute, Fondazione IRCCS Casa Sollievo della Sofferenza Research Hospital, San Giovanni Rotondo, ItalyHuntington and Rare Diseases Unit, CSS-Mendel Institute, Fondazione IRCCS Casa Sollievo della Sofferenza Research Hospital, San Giovanni Rotondo, ItalyItalian League for Research on Huntington Foundation, Rome, ItalyHuntington and Rare Diseases Unit, CSS-Mendel Institute, Fondazione IRCCS Casa Sollievo della Sofferenza Research Hospital, San Giovanni Rotondo, ItalyDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Pathophysiology and Transplantation, “Dino Ferrari Center,” Università degli Studi di Milano, Milan, ItalyBackgroundThe semiology and determinants of apathy are largely unknown across amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Huntington’s disease (HD), due to both motor and non-motor confounders. This study thus aimed at (1) profiling apathy in ALS, PD, and HD and (2) exploring its clinical determinants.MaterialsConsecutive ALS (N = 99), PD (N = 73), and HD (N = 25) patients underwent a motor-free assessment of apathy (Dimensional Apathy Scale, DAS), global cognition, anxiety and depression. Function was assessed through disease-specific scales. The DAS was also completed by N = 101 healthy controls (HCs). Between-group comparisons on DAS scores were implemented by covarying for all applicable confounders. Predictive models on DAS scores were built through multiple, stepwise regressions.ResultsParkinson’s disease and HD, but not ALS, patients were more apathetic than HCs—with HD patients also selectively showing lower initiation and poorer goal-directed planning than HCs. Higher apathetic features were detected in PD and HD as compared to ALS. Education was a protective factor against apathy in ALS. Anxiety was a risk factor for global apathy in ALS, HD, and to a lesser extent, in PD, whereas, protective only toward affective disintegration in PD and ALS. Cognitive inefficiency was a risk factor toward apathy in both PD and ALS. Depression was a risk factor for executive-related apathy in PD.DiscussionThis study provides unprecedented insights into the heterogeneous semiology and determinants of apathy across ALS, PD, and HD via the DAS, in turn informing clinical practice and research.https://www.frontiersin.org/articles/10.3389/fnagi.2022.1031908/fullapathyamyotrophic lateral sclerosisParkinson’s diseaseHuntington’s diseaseneuropsychology |
| spellingShingle | Barbara Poletti Federica Solca Sabrina Maffi Silvia Torre Laura Carelli Edoardo Nicolò Aiello Edoardo Nicolò Aiello Roberta Ferrucci Roberta Ferrucci Roberta Ferrucci Alberto Priori Alberto Priori Alessia Monti Federico Verde Federico Verde Nicola Ticozzi Nicola Ticozzi Simone Migliore Eugenia Scaricamazza Melissa Casella Ferdinando Squitieri Andrea Ciammola Vincenzo Silani Vincenzo Silani Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s disease Frontiers in Aging Neuroscience apathy amyotrophic lateral sclerosis Parkinson’s disease Huntington’s disease neuropsychology |
| title | Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s disease |
| title_full | Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s disease |
| title_fullStr | Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s disease |
| title_full_unstemmed | Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s disease |
| title_short | Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson’s and Huntington’s disease |
| title_sort | semiology and determinants of apathy across neurodegenerative motor disorders a comparison between amyotrophic lateral sclerosis parkinson s and huntington s disease |
| topic | apathy amyotrophic lateral sclerosis Parkinson’s disease Huntington’s disease neuropsychology |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2022.1031908/full |
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