Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study
Data on 2,045 non-demented individuals with memory complaints were drawn from the Memento cohort study to examine the association between Apolipoprotein E ε4 allele (APOE4) and regional brain gray matter volumes. Linear regression was used to examine the association of APOE4 and measures of regional...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811922000957 |
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| author | Mélina Régy Aline Dugravot Séverine Sabia Aurore Fayosse Jean-Francois Mangin Marie Chupin Clara Fischer Vincent Bouteloup Carole Dufouil Geneviève Chêne Claire Paquet Bernard Hanseeuw Archana Singh-Manoux Julien Dumurgier |
| author_facet | Mélina Régy Aline Dugravot Séverine Sabia Aurore Fayosse Jean-Francois Mangin Marie Chupin Clara Fischer Vincent Bouteloup Carole Dufouil Geneviève Chêne Claire Paquet Bernard Hanseeuw Archana Singh-Manoux Julien Dumurgier |
| author_sort | Mélina Régy |
| collection | DOAJ |
| description | Data on 2,045 non-demented individuals with memory complaints were drawn from the Memento cohort study to examine the association between Apolipoprotein E ε4 allele (APOE4) and regional brain gray matter volumes. Linear regression was used to examine the association of APOE4 and measures of regional gray matter volumes in cross-sectional analysis and change therein using longitudinal analyses based on two brain MRI performed at baseline and at two-year follow-up. Overall, in analyses adjusted for age, sex, and intracranial volume, the presence of APOE4 was associated with lower total gray matter volume at baseline and with a higher atrophy rate over the follow-up. The hippocampus and entorhinal cortex were the two gray matter regions most associated with APOE4. Further adjustment for cardiovascular risk factors had little impact on these associations. There was an interaction between age, APOE4 status and total brain volume atrophy rate, with evidence of an earlier age at onset of atrophy in hippocampal volume in APOE4 carriers compared to non-carriers. Those results are in accordance with the role of medial temporal structures in the greater risk of dementia observed in people carrying the APOE4 allele. |
| first_indexed | 2024-12-24T00:26:49Z |
| format | Article |
| id | doaj.art-0a49044bae604158840d746e5e6d9153 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-24T00:26:49Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-0a49044bae604158840d746e5e6d91532022-12-21T17:24:24ZengElsevierNeuroImage1095-95722022-04-01250118966Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort studyMélina Régy0Aline Dugravot1Séverine Sabia2Aurore Fayosse3Jean-Francois Mangin4Marie Chupin5Clara Fischer6Vincent Bouteloup7Carole Dufouil8Geneviève Chêne9Claire Paquet10Bernard Hanseeuw11Archana Singh-Manoux12Julien Dumurgier13Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France; Université catholique de Louvain, Brussels, Belgium; Corresponding author at: Inserm UMR 1153 – EpiAgeing, 10, avenue de Verdun, Paris 75010, France.Université de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, FranceUniversité de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France; University College London, Department of Epidemiology and Public Health, London, United KingdomUniversité de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, FranceUniversité Paris-Saclay, CEA, CNRS, CATI, NeuroSpin, Baobab, Gif sur Yvette, FranceUniversité Paris-Saclay, CEA, CNRS, CATI, NeuroSpin, Baobab, Gif sur Yvette, FranceUniversité Paris-Saclay, CEA, CNRS, CATI, NeuroSpin, Baobab, Gif sur Yvette, FranceUniversité de Bordeaux, Bordeaux, France; Pôle de Santé publique Centre Hospitalier Universitaire de Bordeaux, Inserm, UMR 1219, Inserm, CIC1401-EC, Bordeaux, FranceUniversité de Bordeaux, Bordeaux, France; Pôle de Santé publique Centre Hospitalier Universitaire de Bordeaux, Inserm, UMR 1219, Inserm, CIC1401-EC, Bordeaux, FranceUniversité de Bordeaux, Bordeaux, France; Pôle de Santé publique Centre Hospitalier Universitaire de Bordeaux, Inserm, UMR 1219, Inserm, CIC1401-EC, Bordeaux, FranceGHU APHP Nord Université de Paris Lariboisiere - Fernand Widal Paris, France; Université de Paris, INSERMU1144, Paris FranceUniversité catholique de Louvain, Brussels, Belgium; Cliniques Universitaires Saint-Luc, Brussels, BelgiumUniversité de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France; University College London, Department of Epidemiology and Public Health, London, United KingdomUniversité de Paris, Inserm U1153, Epidemiology of Ageing and Neurodegenerative diseases, Paris, France; GHU APHP Nord Université de Paris Lariboisiere - Fernand Widal Paris, FranceData on 2,045 non-demented individuals with memory complaints were drawn from the Memento cohort study to examine the association between Apolipoprotein E ε4 allele (APOE4) and regional brain gray matter volumes. Linear regression was used to examine the association of APOE4 and measures of regional gray matter volumes in cross-sectional analysis and change therein using longitudinal analyses based on two brain MRI performed at baseline and at two-year follow-up. Overall, in analyses adjusted for age, sex, and intracranial volume, the presence of APOE4 was associated with lower total gray matter volume at baseline and with a higher atrophy rate over the follow-up. The hippocampus and entorhinal cortex were the two gray matter regions most associated with APOE4. Further adjustment for cardiovascular risk factors had little impact on these associations. There was an interaction between age, APOE4 status and total brain volume atrophy rate, with evidence of an earlier age at onset of atrophy in hippocampal volume in APOE4 carriers compared to non-carriers. Those results are in accordance with the role of medial temporal structures in the greater risk of dementia observed in people carrying the APOE4 allele.http://www.sciencedirect.com/science/article/pii/S1053811922000957APOE genotypeMRILongitudinal analysis |
| spellingShingle | Mélina Régy Aline Dugravot Séverine Sabia Aurore Fayosse Jean-Francois Mangin Marie Chupin Clara Fischer Vincent Bouteloup Carole Dufouil Geneviève Chêne Claire Paquet Bernard Hanseeuw Archana Singh-Manoux Julien Dumurgier Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study NeuroImage APOE genotype MRI Longitudinal analysis |
| title | Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study |
| title_full | Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study |
| title_fullStr | Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study |
| title_full_unstemmed | Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study |
| title_short | Association of APOE ε4 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study |
| title_sort | association of apoe ε4 with cerebral gray matter volumes in non demented older adults the memento cohort study |
| topic | APOE genotype MRI Longitudinal analysis |
| url | http://www.sciencedirect.com/science/article/pii/S1053811922000957 |
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