Decoding Non-coding Variants: Recent Approaches to Studying Their Role in Gene Regulation and Human Diseases
Genome-wide association studies (GWAS) have mapped over 90% of disease- and quantitative-trait-associated variants within the non-coding genome. Non-coding regulatory DNA (e.g., promoters and enhancers) and RNA (e.g., 5′ and 3′ UTRs and splice sites) are essential in regulating temporal and tissue-s...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2024-03-01
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| Series: | Frontiers in Bioscience-Scholar |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBS/16/1/10.31083/j.fbs1601004 |