Role of noncoding RNA in the pathophysiology and treatment of intrauterine adhesion
Intrauterine adhesion (IUA) is one of the most common diseases of the reproductive system in women. It is often accompanied by serious clinical problems that damage reproductive function, such as menstrual disorder, infertility, or recurrent abortion. The clinical effect of routine treatment is not...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.948628/full |
| _version_ | 1797943277484244992 |
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| author | Hui-Dong Liu Hui-Dong Liu Shao-Wei Wang Shao-Wei Wang |
| author_facet | Hui-Dong Liu Hui-Dong Liu Shao-Wei Wang Shao-Wei Wang |
| author_sort | Hui-Dong Liu |
| collection | DOAJ |
| description | Intrauterine adhesion (IUA) is one of the most common diseases of the reproductive system in women. It is often accompanied by serious clinical problems that damage reproductive function, such as menstrual disorder, infertility, or recurrent abortion. The clinical effect of routine treatment is not ideal, and the postoperative recurrence rate is still very high. Therefore, exploring the pathological mechanism of IUA and finding new strategies for the effective prevention and treatment of IUA are needed. The main pathological mechanism of IUA is endometrial fibrosis and scar formation. Noncoding RNA (ncRNA) plays an important role in the fibrosis process, which is one of the latest research advances in the pathophysiology of IUA. Moreover, the exosomal miRNAs derived from mesenchymal stem cells can be used to improve IUA. This paper reviewed the role of ncRNAs in IUA pathogenesis, summarized the core pathways of endometrial fibrosis regulated by ncRNAs, and finally introduced the potential of ncRNAs as a therapeutic target. |
| first_indexed | 2024-04-10T20:20:36Z |
| format | Article |
| id | doaj.art-0a4b04d37169465586130fe1708ed072 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-10T20:20:36Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-0a4b04d37169465586130fe1708ed0722023-01-25T18:01:31ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-10-011310.3389/fgene.2022.948628948628Role of noncoding RNA in the pathophysiology and treatment of intrauterine adhesionHui-Dong Liu0Hui-Dong Liu1Shao-Wei Wang2Shao-Wei Wang3Department of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaGraduate School of Peking Union Medical College, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaDepartment of Gynecology and Obstetrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, ChinaGraduate School of Peking Union Medical College, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaIntrauterine adhesion (IUA) is one of the most common diseases of the reproductive system in women. It is often accompanied by serious clinical problems that damage reproductive function, such as menstrual disorder, infertility, or recurrent abortion. The clinical effect of routine treatment is not ideal, and the postoperative recurrence rate is still very high. Therefore, exploring the pathological mechanism of IUA and finding new strategies for the effective prevention and treatment of IUA are needed. The main pathological mechanism of IUA is endometrial fibrosis and scar formation. Noncoding RNA (ncRNA) plays an important role in the fibrosis process, which is one of the latest research advances in the pathophysiology of IUA. Moreover, the exosomal miRNAs derived from mesenchymal stem cells can be used to improve IUA. This paper reviewed the role of ncRNAs in IUA pathogenesis, summarized the core pathways of endometrial fibrosis regulated by ncRNAs, and finally introduced the potential of ncRNAs as a therapeutic target.https://www.frontiersin.org/articles/10.3389/fgene.2022.948628/fullintrauterine adhesionnoncoding-RNAmicroRNAmesenchymal stem cellsexosome |
| spellingShingle | Hui-Dong Liu Hui-Dong Liu Shao-Wei Wang Shao-Wei Wang Role of noncoding RNA in the pathophysiology and treatment of intrauterine adhesion Frontiers in Genetics intrauterine adhesion noncoding-RNA microRNA mesenchymal stem cells exosome |
| title | Role of noncoding RNA in the pathophysiology and treatment of intrauterine adhesion |
| title_full | Role of noncoding RNA in the pathophysiology and treatment of intrauterine adhesion |
| title_fullStr | Role of noncoding RNA in the pathophysiology and treatment of intrauterine adhesion |
| title_full_unstemmed | Role of noncoding RNA in the pathophysiology and treatment of intrauterine adhesion |
| title_short | Role of noncoding RNA in the pathophysiology and treatment of intrauterine adhesion |
| title_sort | role of noncoding rna in the pathophysiology and treatment of intrauterine adhesion |
| topic | intrauterine adhesion noncoding-RNA microRNA mesenchymal stem cells exosome |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.948628/full |
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