Alpha-1 Antitrypsin Attenuates M1 Microglia-Mediated Neuroinflammation in Retinal Degeneration

Alpha-1 Antitrypsin Attenuates M1 Microglia-Mediated Neuroinflammation in Retinal Degeneration

Neurodegenerative diseases are a set of disorders characterized by progressive neuronal death and are associated with microglia-mediated neuroinflammation. Recently, neuroinflammation is proposed as a promising therapeutic target for many neurodegenerative diseases. Alpha-1 antitrypsin (AAT) is reco...

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Bibliographic Details
Main Authors:	Tian Zhou, Zijing Huang, Xiaowei Zhu, Xiaowei Sun, Yan Liu, Bing Cheng, Mei Li, Yizhi Liu, Chang He, Xialin Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-05-01
Series:	Frontiers in Immunology
Subjects:	alpha-1 antitrypsin immunomodulation microglia polarization rd1 mice neuroinflammation
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01202/full

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