The angiotensin receptor neprilysin inhibitor LCZ696 attenuates renal fibrosis via ASK1/JNK/p38 MAPK-mediated apoptosis in unilateral ureteral obstruction.

The angiotensin receptor neprilysin inhibitor LCZ696 attenuates renal fibrosis via ASK1/JNK/p38 MAPK-mediated apoptosis in unilateral ureteral obstruction.

The angiotensin receptor neprilysin inhibitor LCZ696 affords superior cardioprotection and renoprotection compared with renin-angiotensin blockade monotherapy, but the underlying mechanisms remain elusive. Herein, we evaluated whether LCZ696 attenuates renal fibrosis by inhibiting ASK1/JNK/p38 mitog...

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Bibliographic Details
Main Authors: Jun Ding, Sheng Cui, Song Yu Li, Lin Yan Cui, Qi Yan Nan, Xue Jing Lin, Mei Ying Xuan, Jian Jin, Shang Guo Piao, Yu Ji Jiang, Hai Lan Zheng, Ji Zhe Jin, Byung Ha Chung, Chul Woo Yang, Jing Hao Cui, Can Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0286903

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