Carboxylesterases in lipid metabolism: from mouse to human
ABSTRACT Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2017-07-01
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| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1007/s13238-017-0437-z |
| _version_ | 1797725579828527104 |
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| author | Jihong Lian Randal Nelson Richard Lehner |
| author_facet | Jihong Lian Randal Nelson Richard Lehner |
| author_sort | Jihong Lian |
| collection | DOAJ |
| description | ABSTRACT Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro through (over)expression, knockdown of expression, and chemical inhibition in a variety of cells. Recent research advances have revealed the relevance of carboxylesterases to metabolic diseases such as obesity and fatty liver disease, suggesting these enzymes might be potential targets for treatment of metabolic disorders. In order to translate pre-clinical studies in cellular and mouse models to humans, differences and similarities of carboxylesterases between mice and human need to be elucidated. This review presents and discusses the research progress in structure and function of mouse and human carboxylesterases, and the role of these enzymes in lipid metabolism and metabolic disorders. |
| first_indexed | 2024-03-12T10:33:18Z |
| format | Article |
| id | doaj.art-0a50138711574388ad9f5bfd123128aa |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T10:33:18Z |
| publishDate | 2017-07-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-0a50138711574388ad9f5bfd123128aa2023-09-02T09:00:27ZengOxford University PressProtein & Cell1674-800X1674-80182017-07-019217819510.1007/s13238-017-0437-zCarboxylesterases in lipid metabolism: from mouse to humanJihong Lian0Randal Nelson1Richard Lehner2Group on Molecular and Cell Biology of Lipids, University of AlbertaGroup on Molecular and Cell Biology of Lipids, University of AlbertaGroup on Molecular and Cell Biology of Lipids, University of AlbertaABSTRACT Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro through (over)expression, knockdown of expression, and chemical inhibition in a variety of cells. Recent research advances have revealed the relevance of carboxylesterases to metabolic diseases such as obesity and fatty liver disease, suggesting these enzymes might be potential targets for treatment of metabolic disorders. In order to translate pre-clinical studies in cellular and mouse models to humans, differences and similarities of carboxylesterases between mice and human need to be elucidated. This review presents and discusses the research progress in structure and function of mouse and human carboxylesterases, and the role of these enzymes in lipid metabolism and metabolic disorders.http://link.springer.com/article/10.1007/s13238-017-0437-zcarboxylesteraselipaselipidlipoproteinliveradipose |
| spellingShingle | Jihong Lian Randal Nelson Richard Lehner Carboxylesterases in lipid metabolism: from mouse to human Protein & Cell carboxylesterase lipase lipid lipoprotein liver adipose |
| title | Carboxylesterases in lipid metabolism: from mouse to human |
| title_full | Carboxylesterases in lipid metabolism: from mouse to human |
| title_fullStr | Carboxylesterases in lipid metabolism: from mouse to human |
| title_full_unstemmed | Carboxylesterases in lipid metabolism: from mouse to human |
| title_short | Carboxylesterases in lipid metabolism: from mouse to human |
| title_sort | carboxylesterases in lipid metabolism from mouse to human |
| topic | carboxylesterase lipase lipid lipoprotein liver adipose |
| url | http://link.springer.com/article/10.1007/s13238-017-0437-z |
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