DNA Polymerase Theta Plays a Critical Role in Pancreatic Cancer Development and Metastasis

DNA Polymerase Theta Plays a Critical Role in Pancreatic Cancer Development and Metastasis

Pancreatic ductal adenocarcinoma (PDAC), due to its genomic heterogeneity and lack of effective treatment, despite decades of intensive research, will become the second leading cause of cancer-related deaths by 2030. Step-wise acquisition of mutations, due to genomic instability, is considered to dr...

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Bibliographic Details
Main Authors: Agnieszka Smolinska, Kerstin Singer, Janine Golchert, Urszula Smyczynska, Wojciech Fendler, Matthias Sendler, Jens van den Brandt, Stephan Singer, Georg Homuth, Markus M. Lerch, Patryk Moskwa
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
PDAC
DNA repair
non-homologous end joining
polymerase theta
Online Access:https://www.mdpi.com/2072-6694/14/17/4077

Internet

https://www.mdpi.com/2072-6694/14/17/4077

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