Cancer systems immunology
Tumor immunology is undergoing a renaissance due to the recent profound clinical successes of tumor immunotherapy. These advances have coincided with an exponential growth in the development of –omics technologies. Armed with these technologies and their associated computational and modeling toolset...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-07-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/53839 |
| _version_ | 1811180513242644480 |
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| author | Nathan E Reticker-Flynn Edgar G Engleman |
| author_facet | Nathan E Reticker-Flynn Edgar G Engleman |
| author_sort | Nathan E Reticker-Flynn |
| collection | DOAJ |
| description | Tumor immunology is undergoing a renaissance due to the recent profound clinical successes of tumor immunotherapy. These advances have coincided with an exponential growth in the development of –omics technologies. Armed with these technologies and their associated computational and modeling toolsets, systems biologists have turned their attention to tumor immunology in an effort to understand the precise nature and consequences of interactions between tumors and the immune system. Such interactions are inherently multivariate, spanning multiple time and size scales, cell types, and organ systems, rendering systems biology approaches particularly amenable to their interrogation. While in its infancy, the field of ‘Cancer Systems Immunology’ has already influenced our understanding of tumor immunology and immunotherapy. As the field matures, studies will move beyond descriptive characterizations toward functional investigations of the emergent behavior that govern tumor-immune responses. Thus, Cancer Systems Immunology holds incredible promise to advance our ability to fight this disease. |
| first_indexed | 2024-04-11T09:04:32Z |
| format | Article |
| id | doaj.art-0a51c7de44ba4b5fbdd6c5fe12e79fb5 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:04:32Z |
| publishDate | 2020-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-0a51c7de44ba4b5fbdd6c5fe12e79fb52022-12-22T04:32:40ZengeLife Sciences Publications LtdeLife2050-084X2020-07-01910.7554/eLife.53839Cancer systems immunologyNathan E Reticker-Flynn0https://orcid.org/0000-0002-9963-039XEdgar G Engleman1https://orcid.org/0000-0002-2096-9279Department of Pathology, Stanford University School of Medicine, Stanford, United StatesDepartment of Pathology, Stanford University School of Medicine, Stanford, United States; Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, United States; Stanford Cancer Institute, Stanford University, Stanford, United StatesTumor immunology is undergoing a renaissance due to the recent profound clinical successes of tumor immunotherapy. These advances have coincided with an exponential growth in the development of –omics technologies. Armed with these technologies and their associated computational and modeling toolsets, systems biologists have turned their attention to tumor immunology in an effort to understand the precise nature and consequences of interactions between tumors and the immune system. Such interactions are inherently multivariate, spanning multiple time and size scales, cell types, and organ systems, rendering systems biology approaches particularly amenable to their interrogation. While in its infancy, the field of ‘Cancer Systems Immunology’ has already influenced our understanding of tumor immunology and immunotherapy. As the field matures, studies will move beyond descriptive characterizations toward functional investigations of the emergent behavior that govern tumor-immune responses. Thus, Cancer Systems Immunology holds incredible promise to advance our ability to fight this disease.https://elifesciences.org/articles/53839systems biologytumor immunologycancer systems biologysystems immunologytumor immunotherapy |
| spellingShingle | Nathan E Reticker-Flynn Edgar G Engleman Cancer systems immunology eLife systems biology tumor immunology cancer systems biology systems immunology tumor immunotherapy |
| title | Cancer systems immunology |
| title_full | Cancer systems immunology |
| title_fullStr | Cancer systems immunology |
| title_full_unstemmed | Cancer systems immunology |
| title_short | Cancer systems immunology |
| title_sort | cancer systems immunology |
| topic | systems biology tumor immunology cancer systems biology systems immunology tumor immunotherapy |
| url | https://elifesciences.org/articles/53839 |
| work_keys_str_mv | AT nathaneretickerflynn cancersystemsimmunology AT edgargengleman cancersystemsimmunology |