Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice.
Accumulating evidence suggests that the circadian clock is closely associated with metabolic regulation. However, whether an impaired circadian clock is a direct cause of metabolic dysregulation such as body weight gain is not clearly understood. In this study, we demonstrate that body weight gain i...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3499481?pdf=render |
| _version_ | 1819014378688610304 |
|---|---|
| author | Hagoon Jang Gung Lee Jinuk Kong Goun Choi Yoon Jeong Park Jae Bum Kim |
| author_facet | Hagoon Jang Gung Lee Jinuk Kong Goun Choi Yoon Jeong Park Jae Bum Kim |
| author_sort | Hagoon Jang |
| collection | DOAJ |
| description | Accumulating evidence suggests that the circadian clock is closely associated with metabolic regulation. However, whether an impaired circadian clock is a direct cause of metabolic dysregulation such as body weight gain is not clearly understood. In this study, we demonstrate that body weight gain in mice is not significantly changed by restricting feeding period to daytime or nighttime. The expression of peripheral circadian clock genes was altered by feeding period restriction, while the expression of light-regulated hypothalamic circadian clock genes was unaffected by either a normal chow diet (NCD) or a high-fat diet (HFD). In the liver, the expression pattern of circadian clock genes, including Bmal1, Clock, and Per2, was changed by different feeding period restrictions. Moreover, the expression of lipogenic genes, gluconeogenic genes, and fatty acid oxidation-related genes in the liver was also altered by feeding period restriction. Given that feeding period restriction does not affect body weight gain with a NCD or HFD, it is likely that the amount of food consumed might be a crucial factor in determining body weight. Collectively, these data suggest that feeding period restriction modulates the expression of peripheral circadian clock genes, which is uncoupled from light-sensitive hypothalamic circadian clock genes. |
| first_indexed | 2024-12-21T02:14:54Z |
| format | Article |
| id | doaj.art-0a54f620b3a246d894c36d1708a1649e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T02:14:54Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0a54f620b3a246d894c36d1708a1649e2022-12-21T19:19:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01711e4999310.1371/journal.pone.0049993Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice.Hagoon JangGung LeeJinuk KongGoun ChoiYoon Jeong ParkJae Bum KimAccumulating evidence suggests that the circadian clock is closely associated with metabolic regulation. However, whether an impaired circadian clock is a direct cause of metabolic dysregulation such as body weight gain is not clearly understood. In this study, we demonstrate that body weight gain in mice is not significantly changed by restricting feeding period to daytime or nighttime. The expression of peripheral circadian clock genes was altered by feeding period restriction, while the expression of light-regulated hypothalamic circadian clock genes was unaffected by either a normal chow diet (NCD) or a high-fat diet (HFD). In the liver, the expression pattern of circadian clock genes, including Bmal1, Clock, and Per2, was changed by different feeding period restrictions. Moreover, the expression of lipogenic genes, gluconeogenic genes, and fatty acid oxidation-related genes in the liver was also altered by feeding period restriction. Given that feeding period restriction does not affect body weight gain with a NCD or HFD, it is likely that the amount of food consumed might be a crucial factor in determining body weight. Collectively, these data suggest that feeding period restriction modulates the expression of peripheral circadian clock genes, which is uncoupled from light-sensitive hypothalamic circadian clock genes.http://europepmc.org/articles/PMC3499481?pdf=render |
| spellingShingle | Hagoon Jang Gung Lee Jinuk Kong Goun Choi Yoon Jeong Park Jae Bum Kim Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice. PLoS ONE |
| title | Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice. |
| title_full | Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice. |
| title_fullStr | Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice. |
| title_full_unstemmed | Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice. |
| title_short | Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice. |
| title_sort | feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice |
| url | http://europepmc.org/articles/PMC3499481?pdf=render |
| work_keys_str_mv | AT hagoonjang feedingperiodrestrictionalterstheexpressionofperipheralcircadianrhythmgeneswithoutchangingbodyweightinmice AT gunglee feedingperiodrestrictionalterstheexpressionofperipheralcircadianrhythmgeneswithoutchangingbodyweightinmice AT jinukkong feedingperiodrestrictionalterstheexpressionofperipheralcircadianrhythmgeneswithoutchangingbodyweightinmice AT gounchoi feedingperiodrestrictionalterstheexpressionofperipheralcircadianrhythmgeneswithoutchangingbodyweightinmice AT yoonjeongpark feedingperiodrestrictionalterstheexpressionofperipheralcircadianrhythmgeneswithoutchangingbodyweightinmice AT jaebumkim feedingperiodrestrictionalterstheexpressionofperipheralcircadianrhythmgeneswithoutchangingbodyweightinmice |