Circadian remodeling of neuronal circuits involved in rhythmic behavior.
Clock output pathways are central to convey timing information from the circadian clock to a diversity of physiological systems, ranging from cell-autonomous processes to behavior. While the molecular mechanisms that generate and sustain rhythmicity at the cellular level are well understood, it is u...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-03-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC2270325?pdf=render |
| _version_ | 1818894214146031616 |
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| author | María Paz Fernández Jimena Berni María Fernanda Ceriani |
| author_facet | María Paz Fernández Jimena Berni María Fernanda Ceriani |
| author_sort | María Paz Fernández |
| collection | DOAJ |
| description | Clock output pathways are central to convey timing information from the circadian clock to a diversity of physiological systems, ranging from cell-autonomous processes to behavior. While the molecular mechanisms that generate and sustain rhythmicity at the cellular level are well understood, it is unclear how this information is further structured to control specific behavioral outputs. Rhythmic release of pigment dispersing factor (PDF) has been proposed to propagate the time of day information from core pacemaker cells to downstream targets underlying rhythmic locomotor activity. Indeed, such circadian changes in PDF intensity represent the only known mechanism through which the PDF circuit could communicate with its output. Here we describe a novel circadian phenomenon involving extensive remodeling in the axonal terminals of the PDF circuit, which display higher complexity during the day and significantly lower complexity at nighttime, both under daily cycles and constant conditions. In support to its circadian nature, cycling is lost in bona fide clockless mutants. We propose this clock-controlled structural plasticity as a candidate mechanism contributing to the transmission of the information downstream of pacemaker cells. |
| first_indexed | 2024-12-19T18:24:56Z |
| format | Article |
| id | doaj.art-0a58bc06b2ad4c8f93be074688cf46b1 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-19T18:24:56Z |
| publishDate | 2008-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-0a58bc06b2ad4c8f93be074688cf46b12022-12-21T20:10:52ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852008-03-0163e6910.1371/journal.pbio.0060069Circadian remodeling of neuronal circuits involved in rhythmic behavior.María Paz FernándezJimena BerniMaría Fernanda CerianiClock output pathways are central to convey timing information from the circadian clock to a diversity of physiological systems, ranging from cell-autonomous processes to behavior. While the molecular mechanisms that generate and sustain rhythmicity at the cellular level are well understood, it is unclear how this information is further structured to control specific behavioral outputs. Rhythmic release of pigment dispersing factor (PDF) has been proposed to propagate the time of day information from core pacemaker cells to downstream targets underlying rhythmic locomotor activity. Indeed, such circadian changes in PDF intensity represent the only known mechanism through which the PDF circuit could communicate with its output. Here we describe a novel circadian phenomenon involving extensive remodeling in the axonal terminals of the PDF circuit, which display higher complexity during the day and significantly lower complexity at nighttime, both under daily cycles and constant conditions. In support to its circadian nature, cycling is lost in bona fide clockless mutants. We propose this clock-controlled structural plasticity as a candidate mechanism contributing to the transmission of the information downstream of pacemaker cells.http://europepmc.org/articles/PMC2270325?pdf=render |
| spellingShingle | María Paz Fernández Jimena Berni María Fernanda Ceriani Circadian remodeling of neuronal circuits involved in rhythmic behavior. PLoS Biology |
| title | Circadian remodeling of neuronal circuits involved in rhythmic behavior. |
| title_full | Circadian remodeling of neuronal circuits involved in rhythmic behavior. |
| title_fullStr | Circadian remodeling of neuronal circuits involved in rhythmic behavior. |
| title_full_unstemmed | Circadian remodeling of neuronal circuits involved in rhythmic behavior. |
| title_short | Circadian remodeling of neuronal circuits involved in rhythmic behavior. |
| title_sort | circadian remodeling of neuronal circuits involved in rhythmic behavior |
| url | http://europepmc.org/articles/PMC2270325?pdf=render |
| work_keys_str_mv | AT mariapazfernandez circadianremodelingofneuronalcircuitsinvolvedinrhythmicbehavior AT jimenaberni circadianremodelingofneuronalcircuitsinvolvedinrhythmicbehavior AT mariafernandaceriani circadianremodelingofneuronalcircuitsinvolvedinrhythmicbehavior |