Risk of endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia treated with total laparoscopic hysterectomy
Objective: Distinguishing atypical endometrial hyperplasia (AEH) and endometrial cancer (EC) is often difficult, and patients with a preoperative diagnosis of AEH are sometimes diagnosed with EC after hysterectomy. In this study, we assessed the risk factors for EC in patients who underwent total la...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-05-01
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| Series: | Gynecology and Minimally Invasive Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213307016300016 |
| _version_ | 1818958654781521920 |
|---|---|
| author | Katsutoshi Oda Kaori Koga Tetsuya Hirata Masanori Maruyama Masako Ikemura Yoko Matsumoto Kazunori Nagasaka Katsuyuki Adachi Mayuyo Mori-Uchino Kenbun Sone Takahide Arimoto Osamu Wada-Hiraike Kei Kawana Masashi Fukayama Tomoyuki Fujii Yutaka Osuga |
| author_facet | Katsutoshi Oda Kaori Koga Tetsuya Hirata Masanori Maruyama Masako Ikemura Yoko Matsumoto Kazunori Nagasaka Katsuyuki Adachi Mayuyo Mori-Uchino Kenbun Sone Takahide Arimoto Osamu Wada-Hiraike Kei Kawana Masashi Fukayama Tomoyuki Fujii Yutaka Osuga |
| author_sort | Katsutoshi Oda |
| collection | DOAJ |
| description | Objective: Distinguishing atypical endometrial hyperplasia (AEH) and endometrial cancer (EC) is often difficult, and patients with a preoperative diagnosis of AEH are sometimes diagnosed with EC after hysterectomy. In this study, we assessed the risk factors for EC in patients who underwent total laparoscopic hysterectomy (TLH) with a preoperative diagnosis of AEH.
Patients and methods: We retrospectively analyzed 20 patients with a preoperative diagnosis of AEH using endometrial cytology, biopsy (fractional and total curettage), and hysteroscopic inspection.
Results: Four of 20 (20%) patients were diagnosed with EC after TLH, all of whom had endometrioid adenocarcinoma Grade 1 and Stage IA without lymph node metastasis. Four of seven (57%) patients who were highly suspected of having EC by three diagnostic modalities (cytology, fractional curettage, and by hysteroscopy) were diagnosed with EC after TLH, whereas none of the 13 without any suspicious findings in these examinations were diagnosed with EC (p=0.007 by Fisher's exact test). Hysteroscopic findings were positive (suspicious of EC) in six of 11 patients tested, including all four EC patients. However, either endometrial cytology or fractional curettage alone failed to predict cancer in two EC patients. All four EC patients were also suspected of having EC by total curettage. Ovarian preservation was performed in 12 (60%) patients. Three of the four EC patients received subsequent surgery, including pelvic lymphadenectomy.
Conclusion: Careful preoperative examinations, including hysteroscopy, might be useful to evaluate the risk of EC. Accordingly, we should be still careful about the possibility of overdiagnosis in patients with AEH. |
| first_indexed | 2024-12-20T11:29:11Z |
| format | Article |
| id | doaj.art-0a59994eb17b4746a5e8d9ac72b286cf |
| institution | Directory Open Access Journal |
| issn | 2213-3070 |
| language | English |
| last_indexed | 2024-12-20T11:29:11Z |
| publishDate | 2016-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Gynecology and Minimally Invasive Therapy |
| spelling | doaj.art-0a59994eb17b4746a5e8d9ac72b286cf2022-12-21T19:42:17ZengWolters Kluwer Medknow PublicationsGynecology and Minimally Invasive Therapy2213-30702016-05-0152697310.1016/j.gmit.2016.02.001Risk of endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia treated with total laparoscopic hysterectomyKatsutoshi Oda0Kaori Koga1Tetsuya Hirata2Masanori Maruyama3Masako Ikemura4Yoko Matsumoto5Kazunori Nagasaka6Katsuyuki Adachi7Mayuyo Mori-Uchino8Kenbun Sone9Takahide Arimoto10Osamu Wada-Hiraike11Kei Kawana12Masashi Fukayama13Tomoyuki Fujii14Yutaka Osuga15Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Maruyama General Hospital, Saitama, JapanDepartment of Pathology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Pathology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanDepartment of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, JapanObjective: Distinguishing atypical endometrial hyperplasia (AEH) and endometrial cancer (EC) is often difficult, and patients with a preoperative diagnosis of AEH are sometimes diagnosed with EC after hysterectomy. In this study, we assessed the risk factors for EC in patients who underwent total laparoscopic hysterectomy (TLH) with a preoperative diagnosis of AEH. Patients and methods: We retrospectively analyzed 20 patients with a preoperative diagnosis of AEH using endometrial cytology, biopsy (fractional and total curettage), and hysteroscopic inspection. Results: Four of 20 (20%) patients were diagnosed with EC after TLH, all of whom had endometrioid adenocarcinoma Grade 1 and Stage IA without lymph node metastasis. Four of seven (57%) patients who were highly suspected of having EC by three diagnostic modalities (cytology, fractional curettage, and by hysteroscopy) were diagnosed with EC after TLH, whereas none of the 13 without any suspicious findings in these examinations were diagnosed with EC (p=0.007 by Fisher's exact test). Hysteroscopic findings were positive (suspicious of EC) in six of 11 patients tested, including all four EC patients. However, either endometrial cytology or fractional curettage alone failed to predict cancer in two EC patients. All four EC patients were also suspected of having EC by total curettage. Ovarian preservation was performed in 12 (60%) patients. Three of the four EC patients received subsequent surgery, including pelvic lymphadenectomy. Conclusion: Careful preoperative examinations, including hysteroscopy, might be useful to evaluate the risk of EC. Accordingly, we should be still careful about the possibility of overdiagnosis in patients with AEH.http://www.sciencedirect.com/science/article/pii/S2213307016300016atypical endometrial hyperplasiaendometrial cancerhysteroscopytotal curettagetotal laparoscopic hysterectomy |
| spellingShingle | Katsutoshi Oda Kaori Koga Tetsuya Hirata Masanori Maruyama Masako Ikemura Yoko Matsumoto Kazunori Nagasaka Katsuyuki Adachi Mayuyo Mori-Uchino Kenbun Sone Takahide Arimoto Osamu Wada-Hiraike Kei Kawana Masashi Fukayama Tomoyuki Fujii Yutaka Osuga Risk of endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia treated with total laparoscopic hysterectomy Gynecology and Minimally Invasive Therapy atypical endometrial hyperplasia endometrial cancer hysteroscopy total curettage total laparoscopic hysterectomy |
| title | Risk of endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia treated with total laparoscopic hysterectomy |
| title_full | Risk of endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia treated with total laparoscopic hysterectomy |
| title_fullStr | Risk of endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia treated with total laparoscopic hysterectomy |
| title_full_unstemmed | Risk of endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia treated with total laparoscopic hysterectomy |
| title_short | Risk of endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia treated with total laparoscopic hysterectomy |
| title_sort | risk of endometrial cancer in patients with a preoperative diagnosis of atypical endometrial hyperplasia treated with total laparoscopic hysterectomy |
| topic | atypical endometrial hyperplasia endometrial cancer hysteroscopy total curettage total laparoscopic hysterectomy |
| url | http://www.sciencedirect.com/science/article/pii/S2213307016300016 |
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