Effects of Anthocyanin on Intestinal Health: A Systematic Review
Intestinal health relies on the association between the mucosal immune system, intestinal barrier and gut microbiota. Bioactive components that affect the gut microbiota composition, epithelial physical barrier and intestinal morphology were previously studied. The current systematic review evaluate...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/4/1331 |
| _version_ | 1797537298937544704 |
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| author | Thaísa Agrizzi Verediano Hércia Stampini Duarte Martino Maria Cristina Dias Paes Elad Tako |
| author_facet | Thaísa Agrizzi Verediano Hércia Stampini Duarte Martino Maria Cristina Dias Paes Elad Tako |
| author_sort | Thaísa Agrizzi Verediano |
| collection | DOAJ |
| description | Intestinal health relies on the association between the mucosal immune system, intestinal barrier and gut microbiota. Bioactive components that affect the gut microbiota composition, epithelial physical barrier and intestinal morphology were previously studied. The current systematic review evaluated evidence of anthocyanin effects and the ability to improve gut microbiota composition, their metabolites and parameters of the physical barrier; this was conducted in order to answer the question: “Does food source or extract of anthocyanin promote changes on intestinal parameters?”. The data analysis was conducted following the PRISMA guidelines with the search performed at PubMed, Cochrane and Scopus databases for experimental studies, and the risk of bias was assessed by the SYRCLE tool. Twenty-seven studies performed in animal models were included, and evaluated for limitations in heterogeneity, methodologies, absence of information regarding allocation process and investigators’ blinding. The data were analyzed, and the anthocyanin supplementation demonstrated positive effects on intestinal health. The main results identified were an increase of <i>Bacteroidetes</i> and a decrease of <i>Firmicutes</i>, an increase of short chain fatty acids production, a decrease of intestinal pH and intestinal permeability, an increase of the number of goblet cells and tight junction proteins and villi improvement in length or height. Thus, the anthocyanin supplementation has a potential effect to improve the intestinal health. PROSPERO (CRD42020204835). |
| first_indexed | 2024-03-10T12:14:05Z |
| format | Article |
| id | doaj.art-0a59a6fd44b84e3297591c3344a4f3d7 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T12:14:05Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-0a59a6fd44b84e3297591c3344a4f3d72023-11-21T15:59:24ZengMDPI AGNutrients2072-66432021-04-01134133110.3390/nu13041331Effects of Anthocyanin on Intestinal Health: A Systematic ReviewThaísa Agrizzi Verediano0Hércia Stampini Duarte Martino1Maria Cristina Dias Paes2Elad Tako3Department of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-000, MG, BrazilDepartment of Nutrition and Health, Universidade Federal de Viçosa, Viçosa 36570-000, MG, BrazilEmpresa Brasileira de Pesquisa e Agropecuária (EMBRAPA), Sete Lagoas 35701-970, MG, BrazilDepartment of Food Science, Cornell University, Stocking Hall, Ithaca, NY 14850, USAIntestinal health relies on the association between the mucosal immune system, intestinal barrier and gut microbiota. Bioactive components that affect the gut microbiota composition, epithelial physical barrier and intestinal morphology were previously studied. The current systematic review evaluated evidence of anthocyanin effects and the ability to improve gut microbiota composition, their metabolites and parameters of the physical barrier; this was conducted in order to answer the question: “Does food source or extract of anthocyanin promote changes on intestinal parameters?”. The data analysis was conducted following the PRISMA guidelines with the search performed at PubMed, Cochrane and Scopus databases for experimental studies, and the risk of bias was assessed by the SYRCLE tool. Twenty-seven studies performed in animal models were included, and evaluated for limitations in heterogeneity, methodologies, absence of information regarding allocation process and investigators’ blinding. The data were analyzed, and the anthocyanin supplementation demonstrated positive effects on intestinal health. The main results identified were an increase of <i>Bacteroidetes</i> and a decrease of <i>Firmicutes</i>, an increase of short chain fatty acids production, a decrease of intestinal pH and intestinal permeability, an increase of the number of goblet cells and tight junction proteins and villi improvement in length or height. Thus, the anthocyanin supplementation has a potential effect to improve the intestinal health. PROSPERO (CRD42020204835).https://www.mdpi.com/2072-6643/13/4/1331microbiotapolyphenolsshort chain fatty acidsintestinal barrier |
| spellingShingle | Thaísa Agrizzi Verediano Hércia Stampini Duarte Martino Maria Cristina Dias Paes Elad Tako Effects of Anthocyanin on Intestinal Health: A Systematic Review Nutrients microbiota polyphenols short chain fatty acids intestinal barrier |
| title | Effects of Anthocyanin on Intestinal Health: A Systematic Review |
| title_full | Effects of Anthocyanin on Intestinal Health: A Systematic Review |
| title_fullStr | Effects of Anthocyanin on Intestinal Health: A Systematic Review |
| title_full_unstemmed | Effects of Anthocyanin on Intestinal Health: A Systematic Review |
| title_short | Effects of Anthocyanin on Intestinal Health: A Systematic Review |
| title_sort | effects of anthocyanin on intestinal health a systematic review |
| topic | microbiota polyphenols short chain fatty acids intestinal barrier |
| url | https://www.mdpi.com/2072-6643/13/4/1331 |
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