Exploring the Interplay of Uric Acid and Advanced Oxidation Protein Products Following Myocardial Infarction
Recent studies have underscored the potential elevation of Advanced Oxidation Protein Products (AOPP) and uric acid following myocardial infarction, suggesting their involvement in the development and progression of coronary artery disease and potentially influencing patient outcomes. This study foc...
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MDPI AG
2024-02-01
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| Online Access: | https://www.mdpi.com/2076-3417/14/5/1983 |
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| author | Joanna Sikora Tomasz Wybranowski Aleksandra Karczmarska-Wódzka Przemysław Sobczak Stefan Kruszewski Zbigniew Włodarczyk |
| author_facet | Joanna Sikora Tomasz Wybranowski Aleksandra Karczmarska-Wódzka Przemysław Sobczak Stefan Kruszewski Zbigniew Włodarczyk |
| author_sort | Joanna Sikora |
| collection | DOAJ |
| description | Recent studies have underscored the potential elevation of Advanced Oxidation Protein Products (AOPP) and uric acid following myocardial infarction, suggesting their involvement in the development and progression of coronary artery disease and potentially influencing patient outcomes. This study focuses explicitly on examining uric acid and AOPP in the same patients to address the research gap in these biomarkers’ interplay. Recognizing the dual character of uric acid as both an antioxidant and a pro-oxidant, this study delves into its complex biological implications. An analysis was conducted on 40 patients who had experienced myocardial infarction. AOPP levels were quantified using absorbance at 340 nm. Results demonstrated significantly increased AOPP levels in myocardial infarction patients compared to healthy controls, especially in those with high serum uric acid. The serum uric acid and AOPP relationship exhibits a J-shaped curve, indicating a complex, multifactorial interaction. These findings offer new insights into the intricate relationship between serum uric acid and AOPP in myocardial infarction patients, underscoring the significance of these biomarkers in enhancing our understanding of clinical outcomes and informing targeted management strategies for coronary artery disease. |
| first_indexed | 2024-04-25T00:35:00Z |
| format | Article |
| id | doaj.art-0a5ad97e8b854c24a8a59547aedae7fc |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-04-25T00:35:00Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-0a5ad97e8b854c24a8a59547aedae7fc2024-03-12T16:39:41ZengMDPI AGApplied Sciences2076-34172024-02-01145198310.3390/app14051983Exploring the Interplay of Uric Acid and Advanced Oxidation Protein Products Following Myocardial InfarctionJoanna Sikora0Tomasz Wybranowski1Aleksandra Karczmarska-Wódzka2Przemysław Sobczak3Stefan Kruszewski4Zbigniew Włodarczyk5Research and Education Unit for Experimental Biotechnology, Department of Transplantology and General Surgery, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-094 Bydgoszcz, PolandDepartment of Biophysics, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandResearch and Education Unit for Experimental Biotechnology, Department of Transplantology and General Surgery, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-094 Bydgoszcz, PolandDr Jan Biziel’s University Hospital, Ujejskiego Street 75, 85-168 Bydgoszcz, PolandDepartment of Biophysics, Faculty of Pharmacy, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandDepartment of Transplantology and General Surgery, Faculty of Medicine, Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandRecent studies have underscored the potential elevation of Advanced Oxidation Protein Products (AOPP) and uric acid following myocardial infarction, suggesting their involvement in the development and progression of coronary artery disease and potentially influencing patient outcomes. This study focuses explicitly on examining uric acid and AOPP in the same patients to address the research gap in these biomarkers’ interplay. Recognizing the dual character of uric acid as both an antioxidant and a pro-oxidant, this study delves into its complex biological implications. An analysis was conducted on 40 patients who had experienced myocardial infarction. AOPP levels were quantified using absorbance at 340 nm. Results demonstrated significantly increased AOPP levels in myocardial infarction patients compared to healthy controls, especially in those with high serum uric acid. The serum uric acid and AOPP relationship exhibits a J-shaped curve, indicating a complex, multifactorial interaction. These findings offer new insights into the intricate relationship between serum uric acid and AOPP in myocardial infarction patients, underscoring the significance of these biomarkers in enhancing our understanding of clinical outcomes and informing targeted management strategies for coronary artery disease.https://www.mdpi.com/2076-3417/14/5/1983uric acidcardiovascular diseasesmyocardial infarctionadvanced oxidation protein productsreactive oxygen species |
| spellingShingle | Joanna Sikora Tomasz Wybranowski Aleksandra Karczmarska-Wódzka Przemysław Sobczak Stefan Kruszewski Zbigniew Włodarczyk Exploring the Interplay of Uric Acid and Advanced Oxidation Protein Products Following Myocardial Infarction Applied Sciences uric acid cardiovascular diseases myocardial infarction advanced oxidation protein products reactive oxygen species |
| title | Exploring the Interplay of Uric Acid and Advanced Oxidation Protein Products Following Myocardial Infarction |
| title_full | Exploring the Interplay of Uric Acid and Advanced Oxidation Protein Products Following Myocardial Infarction |
| title_fullStr | Exploring the Interplay of Uric Acid and Advanced Oxidation Protein Products Following Myocardial Infarction |
| title_full_unstemmed | Exploring the Interplay of Uric Acid and Advanced Oxidation Protein Products Following Myocardial Infarction |
| title_short | Exploring the Interplay of Uric Acid and Advanced Oxidation Protein Products Following Myocardial Infarction |
| title_sort | exploring the interplay of uric acid and advanced oxidation protein products following myocardial infarction |
| topic | uric acid cardiovascular diseases myocardial infarction advanced oxidation protein products reactive oxygen species |
| url | https://www.mdpi.com/2076-3417/14/5/1983 |
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