The Roles of T Helper 1, T Helper 17 and Regulatory T Cells in the Pathogenesis of Sarcoidosis
Sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. It is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. The balance between Th1, Th17 and Regulatory T(Treg) cells controls T-cell prolifer...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2016-08-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/695 |
| _version_ | 1818015413634596864 |
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| author | Esmaeil Mortaz Fatemeh Rezayat Davar Amani Arda Kiani Johan Garssen Ian M. Adcock Aliakbar Velayati |
| author_facet | Esmaeil Mortaz Fatemeh Rezayat Davar Amani Arda Kiani Johan Garssen Ian M. Adcock Aliakbar Velayati |
| author_sort | Esmaeil Mortaz |
| collection | DOAJ |
| description | Sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. It is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. The balance between Th1, Th17 and Regulatory T(Treg) cells controls T-cell proliferation and activation.The Th17/Treg ratio in the peripheral blood and bronchoalveolar lavage fluidis increased in patients with active sarcoidosis. Amplified IL-17A expression in granulomas and the presence of IL-17A+, IL-17A+IL-4+ and IL-17A+IFN-γ+ memory T helper cells in the circulation and BAL indicate Th17 cell involvement in granuloma induction and/or maintenance in sarcoidosis. Sarcoidosis should therefore be considered as a Th1/Th17 multisystem disorder and anti-IL-17/Th17 approaches that control and reduce IL-17Amay be an option, therefore, for the treatment of sarcoidosis.Here we provide a short overview as to the role of Th17 cells as critical cells in the pathogenesis of sarcoidosis. |
| first_indexed | 2024-04-14T06:56:44Z |
| format | Article |
| id | doaj.art-0a5ae738035a4c65966c5c3a42d172ad |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-04-14T06:56:44Z |
| publishDate | 2016-08-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-0a5ae738035a4c65966c5c3a42d172ad2022-12-22T02:06:51ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492016-08-01154632The Roles of T Helper 1, T Helper 17 and Regulatory T Cells in the Pathogenesis of SarcoidosisEsmaeil Mortaz0Fatemeh Rezayat1Davar Amani2Arda Kiani3Johan Garssen4Ian M. Adcock5Aliakbar Velayati6Department of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Chronic Respiratory Diseases Research Center and National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Department of Immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UKDepartment of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, IranChronic Respiratory Diseases Research Center and National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Department of Immunology, Shahid Beheshti University of Medical Sciences, Tehran, IranDivision of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The NetherlandsAirways Disease Section, National Heart and Lung Institute, Imperial College London, London, UKMycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranSarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. It is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. The balance between Th1, Th17 and Regulatory T(Treg) cells controls T-cell proliferation and activation.The Th17/Treg ratio in the peripheral blood and bronchoalveolar lavage fluidis increased in patients with active sarcoidosis. Amplified IL-17A expression in granulomas and the presence of IL-17A+, IL-17A+IL-4+ and IL-17A+IFN-γ+ memory T helper cells in the circulation and BAL indicate Th17 cell involvement in granuloma induction and/or maintenance in sarcoidosis. Sarcoidosis should therefore be considered as a Th1/Th17 multisystem disorder and anti-IL-17/Th17 approaches that control and reduce IL-17Amay be an option, therefore, for the treatment of sarcoidosis.Here we provide a short overview as to the role of Th17 cells as critical cells in the pathogenesis of sarcoidosis.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/695GranulomaInterleukin 17SarcoidosisTh17 cell |
| spellingShingle | Esmaeil Mortaz Fatemeh Rezayat Davar Amani Arda Kiani Johan Garssen Ian M. Adcock Aliakbar Velayati The Roles of T Helper 1, T Helper 17 and Regulatory T Cells in the Pathogenesis of Sarcoidosis Iranian Journal of Allergy, Asthma and Immunology Granuloma Interleukin 17 Sarcoidosis Th17 cell |
| title | The Roles of T Helper 1, T Helper 17 and Regulatory T Cells in the Pathogenesis of Sarcoidosis |
| title_full | The Roles of T Helper 1, T Helper 17 and Regulatory T Cells in the Pathogenesis of Sarcoidosis |
| title_fullStr | The Roles of T Helper 1, T Helper 17 and Regulatory T Cells in the Pathogenesis of Sarcoidosis |
| title_full_unstemmed | The Roles of T Helper 1, T Helper 17 and Regulatory T Cells in the Pathogenesis of Sarcoidosis |
| title_short | The Roles of T Helper 1, T Helper 17 and Regulatory T Cells in the Pathogenesis of Sarcoidosis |
| title_sort | roles of t helper 1 t helper 17 and regulatory t cells in the pathogenesis of sarcoidosis |
| topic | Granuloma Interleukin 17 Sarcoidosis Th17 cell |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/695 |
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