A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system.
Unlike other monoamine neurotransmitters, the mechanism by which the brain's histamine content is regulated remains unclear. In mammals, vesicular monoamine transporters (VMATs) are expressed exclusively in neurons and mediate the storage of histamine and other monoamines. We have studied the v...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-11-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC2570955?pdf=render |
| _version_ | 1818141177131565056 |
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| author | Rafael Romero-Calderón Guido Uhlenbrock Jolanta Borycz Anne F Simon Anna Grygoruk Susan K Yee Amy Shyer Larry C Ackerson Nigel T Maidment Ian A Meinertzhagen Bernhard T Hovemann David E Krantz |
| author_facet | Rafael Romero-Calderón Guido Uhlenbrock Jolanta Borycz Anne F Simon Anna Grygoruk Susan K Yee Amy Shyer Larry C Ackerson Nigel T Maidment Ian A Meinertzhagen Bernhard T Hovemann David E Krantz |
| author_sort | Rafael Romero-Calderón |
| collection | DOAJ |
| description | Unlike other monoamine neurotransmitters, the mechanism by which the brain's histamine content is regulated remains unclear. In mammals, vesicular monoamine transporters (VMATs) are expressed exclusively in neurons and mediate the storage of histamine and other monoamines. We have studied the visual system of Drosophila melanogaster in which histamine is the primary neurotransmitter released from photoreceptor cells. We report here that a novel mRNA splice variant of Drosophila VMAT (DVMAT-B) is expressed not in neurons but rather in a small subset of glia in the lamina of the fly's optic lobe. Histamine contents are reduced by mutation of dVMAT, but can be partially restored by specifically expressing DVMAT-B in glia. Our results suggest a novel role for a monoamine transporter in glia that may be relevant to histamine homeostasis in other systems. |
| first_indexed | 2024-12-11T10:55:44Z |
| format | Article |
| id | doaj.art-0a5c04b346044691ac0fa50256b893da |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-11T10:55:44Z |
| publishDate | 2008-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-0a5c04b346044691ac0fa50256b893da2022-12-22T01:10:04ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042008-11-01411e100024510.1371/journal.pgen.1000245A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system.Rafael Romero-CalderónGuido UhlenbrockJolanta BoryczAnne F SimonAnna GrygorukSusan K YeeAmy ShyerLarry C AckersonNigel T MaidmentIan A MeinertzhagenBernhard T HovemannDavid E KrantzUnlike other monoamine neurotransmitters, the mechanism by which the brain's histamine content is regulated remains unclear. In mammals, vesicular monoamine transporters (VMATs) are expressed exclusively in neurons and mediate the storage of histamine and other monoamines. We have studied the visual system of Drosophila melanogaster in which histamine is the primary neurotransmitter released from photoreceptor cells. We report here that a novel mRNA splice variant of Drosophila VMAT (DVMAT-B) is expressed not in neurons but rather in a small subset of glia in the lamina of the fly's optic lobe. Histamine contents are reduced by mutation of dVMAT, but can be partially restored by specifically expressing DVMAT-B in glia. Our results suggest a novel role for a monoamine transporter in glia that may be relevant to histamine homeostasis in other systems.http://europepmc.org/articles/PMC2570955?pdf=render |
| spellingShingle | Rafael Romero-Calderón Guido Uhlenbrock Jolanta Borycz Anne F Simon Anna Grygoruk Susan K Yee Amy Shyer Larry C Ackerson Nigel T Maidment Ian A Meinertzhagen Bernhard T Hovemann David E Krantz A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system. PLoS Genetics |
| title | A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system. |
| title_full | A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system. |
| title_fullStr | A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system. |
| title_full_unstemmed | A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system. |
| title_short | A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system. |
| title_sort | glial variant of the vesicular monoamine transporter is required to store histamine in the drosophila visual system |
| url | http://europepmc.org/articles/PMC2570955?pdf=render |
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