Neural mechanism of the relationship between sleep efficiency and clinical improvement in major depressive disorder: A longitudinal functional magnetic resonance imaging study
BackgroundAntidepressants represent the most common treatment of choice for major depressive disorder (MDD). In this study, we aimed to explore the status-related changes (acute vs. remitted status) in brain function in patients with MDD.MethodsRegular antidepressant medications (an average of 7 mon...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1027141/full |
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| author | Tao Chen Tao Chen Tao Chen Wenming Zhao Yu Zhang Yu Zhang Yu Zhang Jiakuai Yu Jiakuai Yu Jiakuai Yu Ting Wang Ting Wang Ting Wang Jiajia Zhang Jiajia Zhang Jiajia Zhang Yifei Li Yifei Li Yifei Li Jiajia Zhu Dao-min Zhu Dao-min Zhu Dao-min Zhu |
| author_facet | Tao Chen Tao Chen Tao Chen Wenming Zhao Yu Zhang Yu Zhang Yu Zhang Jiakuai Yu Jiakuai Yu Jiakuai Yu Ting Wang Ting Wang Ting Wang Jiajia Zhang Jiajia Zhang Jiajia Zhang Yifei Li Yifei Li Yifei Li Jiajia Zhu Dao-min Zhu Dao-min Zhu Dao-min Zhu |
| author_sort | Tao Chen |
| collection | DOAJ |
| description | BackgroundAntidepressants represent the most common treatment of choice for major depressive disorder (MDD). In this study, we aimed to explore the status-related changes (acute vs. remitted status) in brain function in patients with MDD.MethodsRegular antidepressant medications (an average of 7 months after the initial visit, remitted status) were received by 48 patients with MDD. All the patients underwent MRI and polysomnography examinations as well as clinical assessment at each visit.ResultsWe found that baseline fractional amplitude of low-frequency fluctuations (fALFF) of right superior parietal gyrus (SPG) and middle frontal gyrus could predict depression and anxiety symptoms improvement from acute to remitted status in patients with MDD, respectively. Moreover, we found a significant positive correlation between the fALFF of right SPG and baseline sleep efficiency (SE) in patients with MDD. Further mediation analysis revealed that the fALFF of right SPG mediated the relationship between baseline SE and depressive symptom improvement.ConclusionApart from highlighting the fALFF as a potential prognostic indicator to predict and track disease progression in patients with MDD, these findings might provide a neural mechanism basis for improving sleep quality of patients with MDD and thus promoting the recovery of clinical symptoms, as well as provide a practical basis for clinical interventions in patients with MDD with sleep disorders. |
| first_indexed | 2024-04-12T13:56:31Z |
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| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-12T13:56:31Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-0a5dd1e0f48c4a1abe1103c69b70d3b22022-12-22T03:30:20ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-10-011310.3389/fpsyt.2022.10271411027141Neural mechanism of the relationship between sleep efficiency and clinical improvement in major depressive disorder: A longitudinal functional magnetic resonance imaging studyTao Chen0Tao Chen1Tao Chen2Wenming Zhao3Yu Zhang4Yu Zhang5Yu Zhang6Jiakuai Yu7Jiakuai Yu8Jiakuai Yu9Ting Wang10Ting Wang11Ting Wang12Jiajia Zhang13Jiajia Zhang14Jiajia Zhang15Yifei Li16Yifei Li17Yifei Li18Jiajia Zhu19Dao-min Zhu20Dao-min Zhu21Dao-min Zhu22Department of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaHefei Fourth People’s Hospital, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaHefei Fourth People’s Hospital, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaHefei Fourth People’s Hospital, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaHefei Fourth People’s Hospital, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaHefei Fourth People’s Hospital, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaHefei Fourth People’s Hospital, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaDepartment of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, ChinaHefei Fourth People’s Hospital, Hefei, ChinaAnhui Mental Health Center, Hefei, ChinaBackgroundAntidepressants represent the most common treatment of choice for major depressive disorder (MDD). In this study, we aimed to explore the status-related changes (acute vs. remitted status) in brain function in patients with MDD.MethodsRegular antidepressant medications (an average of 7 months after the initial visit, remitted status) were received by 48 patients with MDD. All the patients underwent MRI and polysomnography examinations as well as clinical assessment at each visit.ResultsWe found that baseline fractional amplitude of low-frequency fluctuations (fALFF) of right superior parietal gyrus (SPG) and middle frontal gyrus could predict depression and anxiety symptoms improvement from acute to remitted status in patients with MDD, respectively. Moreover, we found a significant positive correlation between the fALFF of right SPG and baseline sleep efficiency (SE) in patients with MDD. Further mediation analysis revealed that the fALFF of right SPG mediated the relationship between baseline SE and depressive symptom improvement.ConclusionApart from highlighting the fALFF as a potential prognostic indicator to predict and track disease progression in patients with MDD, these findings might provide a neural mechanism basis for improving sleep quality of patients with MDD and thus promoting the recovery of clinical symptoms, as well as provide a practical basis for clinical interventions in patients with MDD with sleep disorders.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1027141/fullmajor depressive disorderfunctional magnetic resonance imagingclinical symptomspolysomnographysleep efficiency |
| spellingShingle | Tao Chen Tao Chen Tao Chen Wenming Zhao Yu Zhang Yu Zhang Yu Zhang Jiakuai Yu Jiakuai Yu Jiakuai Yu Ting Wang Ting Wang Ting Wang Jiajia Zhang Jiajia Zhang Jiajia Zhang Yifei Li Yifei Li Yifei Li Jiajia Zhu Dao-min Zhu Dao-min Zhu Dao-min Zhu Neural mechanism of the relationship between sleep efficiency and clinical improvement in major depressive disorder: A longitudinal functional magnetic resonance imaging study Frontiers in Psychiatry major depressive disorder functional magnetic resonance imaging clinical symptoms polysomnography sleep efficiency |
| title | Neural mechanism of the relationship between sleep efficiency and clinical improvement in major depressive disorder: A longitudinal functional magnetic resonance imaging study |
| title_full | Neural mechanism of the relationship between sleep efficiency and clinical improvement in major depressive disorder: A longitudinal functional magnetic resonance imaging study |
| title_fullStr | Neural mechanism of the relationship between sleep efficiency and clinical improvement in major depressive disorder: A longitudinal functional magnetic resonance imaging study |
| title_full_unstemmed | Neural mechanism of the relationship between sleep efficiency and clinical improvement in major depressive disorder: A longitudinal functional magnetic resonance imaging study |
| title_short | Neural mechanism of the relationship between sleep efficiency and clinical improvement in major depressive disorder: A longitudinal functional magnetic resonance imaging study |
| title_sort | neural mechanism of the relationship between sleep efficiency and clinical improvement in major depressive disorder a longitudinal functional magnetic resonance imaging study |
| topic | major depressive disorder functional magnetic resonance imaging clinical symptoms polysomnography sleep efficiency |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1027141/full |
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