Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity

Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity

Membrane heparan sulfate proteoglycans (HSPG) regulate cell proliferation, migration, and differentiation and are therefore considered key players in cancer cell development processes. Here, we used the NT4 peptide to investigate how the sulfation pattern of HSPG on cells drives binding specificity....

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Bibliographic Details
Main Authors: Jlenia Brunetti, Giulia Riolo, Lorenzo Depau, Elisabetta Mandarini, Andrea Bernini, Evgenia Karousou, Alberto Passi, Alessandro Pini, Luisa Bracci, Chiara Falciani
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Oncology
Subjects:
heparan sulfate proteoglycans
peptide
tumor targeting
sulfatase
oligosaccharide
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00843/full

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