Analysis of risk factors related to nonalcoholic fatty liver disease: a retrospective study based on 31,718 adult Chinese individuals
ObjectiveNonalcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide. This study guides the prevention and diagnosis of NAFLD by analyzing its risk factors and the diagnostic value of each index for NAFLD.MethodWe collected the clinical information of adults individuals who...
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1168499/full |
| _version_ | 1797792269517979648 |
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| author | Ganggang Wang Ganggang Wang Xiaowei Shen Yicun Wang Huanhua Lu Hua He Xiaoliang Wang Xiaoliang Wang |
| author_facet | Ganggang Wang Ganggang Wang Xiaowei Shen Yicun Wang Huanhua Lu Hua He Xiaoliang Wang Xiaoliang Wang |
| author_sort | Ganggang Wang |
| collection | DOAJ |
| description | ObjectiveNonalcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide. This study guides the prevention and diagnosis of NAFLD by analyzing its risk factors and the diagnostic value of each index for NAFLD.MethodWe collected the clinical information of adults individuals who underwent physical examination in the Physical Examination Center of Qingpu Branch of Zhongshan Hospital, Fudan University, from January 2016 to January 2020, including gender, age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL). We performed logistic regression analysis and ROC diagnostic analysis.ResultsThe results showed that age, BMI, SBP, ALT, AST, FBG, TBIL, TG, and LDL were risk factors for NAFLD in adults, and HDL was a protective factor (all p-values were less than 0.05). Among them, age, BMI, ALT, TG, and HDL had a predictive value for the occurrence of NAFLD in the adults (AUC = 0.708, 0.836, 0.767, 0.780, and 0.732, respectively). The combination of age, BMI, ALT, TG, and HDL had a diagnostic value for the occurrence of NAFLD (AUC = 0.881).ConclusionHealthy people should pay attention to their BMI levels, manage blood pressure, blood glucose, and lipid levels, and pay attention to changes in ALT and AST index levels to prevent NAFLD. Age, BMI, ALT, TG, and HDL indexes are helpful factors in the diagnosis of NAFLD. |
| first_indexed | 2024-03-13T02:30:46Z |
| format | Article |
| id | doaj.art-0a619d8fbd464472bb3e8c1b5755dc3e |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T02:30:46Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-0a619d8fbd464472bb3e8c1b5755dc3e2023-06-29T14:06:49ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-06-011010.3389/fmed.2023.11684991168499Analysis of risk factors related to nonalcoholic fatty liver disease: a retrospective study based on 31,718 adult Chinese individualsGanggang Wang0Ganggang Wang1Xiaowei Shen2Yicun Wang3Huanhua Lu4Hua He5Xiaoliang Wang6Xiaoliang Wang7Department of Hepatobiliary Surgery, Pudong Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, ChinaDepartment of Hepatobiliary Surgery, Pudong Hospital, Fudan University, Shanghai, ChinaDepartment of General Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, ChinaObjectiveNonalcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide. This study guides the prevention and diagnosis of NAFLD by analyzing its risk factors and the diagnostic value of each index for NAFLD.MethodWe collected the clinical information of adults individuals who underwent physical examination in the Physical Examination Center of Qingpu Branch of Zhongshan Hospital, Fudan University, from January 2016 to January 2020, including gender, age, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL). We performed logistic regression analysis and ROC diagnostic analysis.ResultsThe results showed that age, BMI, SBP, ALT, AST, FBG, TBIL, TG, and LDL were risk factors for NAFLD in adults, and HDL was a protective factor (all p-values were less than 0.05). Among them, age, BMI, ALT, TG, and HDL had a predictive value for the occurrence of NAFLD in the adults (AUC = 0.708, 0.836, 0.767, 0.780, and 0.732, respectively). The combination of age, BMI, ALT, TG, and HDL had a diagnostic value for the occurrence of NAFLD (AUC = 0.881).ConclusionHealthy people should pay attention to their BMI levels, manage blood pressure, blood glucose, and lipid levels, and pay attention to changes in ALT and AST index levels to prevent NAFLD. Age, BMI, ALT, TG, and HDL indexes are helpful factors in the diagnosis of NAFLD.https://www.frontiersin.org/articles/10.3389/fmed.2023.1168499/fullNAFLDrisk factorslogistic regressionROC diagnosisprevention |
| spellingShingle | Ganggang Wang Ganggang Wang Xiaowei Shen Yicun Wang Huanhua Lu Hua He Xiaoliang Wang Xiaoliang Wang Analysis of risk factors related to nonalcoholic fatty liver disease: a retrospective study based on 31,718 adult Chinese individuals Frontiers in Medicine NAFLD risk factors logistic regression ROC diagnosis prevention |
| title | Analysis of risk factors related to nonalcoholic fatty liver disease: a retrospective study based on 31,718 adult Chinese individuals |
| title_full | Analysis of risk factors related to nonalcoholic fatty liver disease: a retrospective study based on 31,718 adult Chinese individuals |
| title_fullStr | Analysis of risk factors related to nonalcoholic fatty liver disease: a retrospective study based on 31,718 adult Chinese individuals |
| title_full_unstemmed | Analysis of risk factors related to nonalcoholic fatty liver disease: a retrospective study based on 31,718 adult Chinese individuals |
| title_short | Analysis of risk factors related to nonalcoholic fatty liver disease: a retrospective study based on 31,718 adult Chinese individuals |
| title_sort | analysis of risk factors related to nonalcoholic fatty liver disease a retrospective study based on 31 718 adult chinese individuals |
| topic | NAFLD risk factors logistic regression ROC diagnosis prevention |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1168499/full |
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