Modeling of Ternary Solid-Liquid-Equilibria for Pharmaceutical and Food Systems
The present work deals with the modeling of solid-liquid equilibria (SLE) using the NRTL and the UNIFAC thermodynamic models for activity coefficient calculation, for a number of ternary systems involving pharmaceutical and food compounds such as salicylic acid, nicotic acid, caffeine, urea, vanilli...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIDIC Servizi S.r.l.
2015-05-01
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| Series: | Chemical Engineering Transactions |
| Online Access: | https://www.cetjournal.it/index.php/cet/article/view/5080 |
| _version_ | 1819053657581158400 |
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| author | K. Bitchikh A.H. Meniai W. Louaer |
| author_facet | K. Bitchikh A.H. Meniai W. Louaer |
| author_sort | K. Bitchikh |
| collection | DOAJ |
| description | The present work deals with the modeling of solid-liquid equilibria (SLE) using the NRTL and the UNIFAC thermodynamic models for activity coefficient calculation, for a number of ternary systems involving pharmaceutical and food compounds such as salicylic acid, nicotic acid, caffeine, urea, vanillin, etc. as the solutes and water-ethanol and water-methanol as the solvent pairs, at different temperatures.
For the UNIFAC model interaction parameters were available whereas for the NRTL model they were retrieved from the experimentally measured values using the Simplex method to minimize an objective function expressed as a summation of the squared differences between the experimental and the calculated values, to be used to predict the SLE data for the considered systems with a quite good agreement. |
| first_indexed | 2024-12-21T12:39:13Z |
| format | Article |
| id | doaj.art-0a62f5674aba4104b03560b8d2285698 |
| institution | Directory Open Access Journal |
| issn | 2283-9216 |
| language | English |
| last_indexed | 2024-12-21T12:39:13Z |
| publishDate | 2015-05-01 |
| publisher | AIDIC Servizi S.r.l. |
| record_format | Article |
| series | Chemical Engineering Transactions |
| spelling | doaj.art-0a62f5674aba4104b03560b8d22856982022-12-21T19:03:49ZengAIDIC Servizi S.r.l.Chemical Engineering Transactions2283-92162015-05-014310.3303/CET1543313Modeling of Ternary Solid-Liquid-Equilibria for Pharmaceutical and Food SystemsK. BitchikhA.H. MeniaiW. LouaerThe present work deals with the modeling of solid-liquid equilibria (SLE) using the NRTL and the UNIFAC thermodynamic models for activity coefficient calculation, for a number of ternary systems involving pharmaceutical and food compounds such as salicylic acid, nicotic acid, caffeine, urea, vanillin, etc. as the solutes and water-ethanol and water-methanol as the solvent pairs, at different temperatures. For the UNIFAC model interaction parameters were available whereas for the NRTL model they were retrieved from the experimentally measured values using the Simplex method to minimize an objective function expressed as a summation of the squared differences between the experimental and the calculated values, to be used to predict the SLE data for the considered systems with a quite good agreement.https://www.cetjournal.it/index.php/cet/article/view/5080 |
| spellingShingle | K. Bitchikh A.H. Meniai W. Louaer Modeling of Ternary Solid-Liquid-Equilibria for Pharmaceutical and Food Systems Chemical Engineering Transactions |
| title | Modeling of Ternary Solid-Liquid-Equilibria for Pharmaceutical and Food Systems |
| title_full | Modeling of Ternary Solid-Liquid-Equilibria for Pharmaceutical and Food Systems |
| title_fullStr | Modeling of Ternary Solid-Liquid-Equilibria for Pharmaceutical and Food Systems |
| title_full_unstemmed | Modeling of Ternary Solid-Liquid-Equilibria for Pharmaceutical and Food Systems |
| title_short | Modeling of Ternary Solid-Liquid-Equilibria for Pharmaceutical and Food Systems |
| title_sort | modeling of ternary solid liquid equilibria for pharmaceutical and food systems |
| url | https://www.cetjournal.it/index.php/cet/article/view/5080 |
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