History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs
Gastric acid-related disorders are commonly encountered in clinical practice. Acetylcholine, gastrin, and histamine are physiological agonists that stimulate acid secretion from parietal cells. Histamine plays a decisive role in the transformation of parietal cells into acid-secreting forms. The H+,...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Yong Chan Lee
2023-09-01
|
| Series: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| Subjects: | |
| Online Access: | http://www.helicojournal.org/upload/pdf/kjhugr-2023-0040.pdf |
| _version_ | 1797686685887102976 |
|---|---|
| author | Dong Han Yeom Yong Sung Kim |
| author_facet | Dong Han Yeom Yong Sung Kim |
| author_sort | Dong Han Yeom |
| collection | DOAJ |
| description | Gastric acid-related disorders are commonly encountered in clinical practice. Acetylcholine, gastrin, and histamine are physiological agonists that stimulate acid secretion from parietal cells. Histamine plays a decisive role in the transformation of parietal cells into acid-secreting forms. The H+, K+- ATPase proton pump, which represents the final step of acid secretion, translocates from cytoplasmic tubulovesicles to secretory canaliculi upon parietal cell stimulation and facilitates exchange of intracellular H+ with extracellular K+ in a 1:1 ratio. Histamine-2 receptor antagonists and proton pump inhibitors (PPIs) are widely used in clinical practice, and potassium-competitive acid blockers (P-CABs) have gained attention in recent times. P-CABs address the unmet needs of patients who receive conventional PPIs and have broadened the spectrum of drug choices; however, further research is warranted to confirm long-term safety of these drugs. Comprehensive understanding of the mechanisms of actions, characteristics, advantages and disadvantages, and the adverse effect profile is essential for appropriate prescription of gastric acid-suppressive drugs. In this review, we provide a developing history and outline the pharmacological mechanisms underlying various gastric acid-suppressive drugs used in clinical settings. |
| first_indexed | 2024-03-12T01:08:26Z |
| format | Article |
| id | doaj.art-0a631016ca8b45b3acaf2a49e0244b54 |
| institution | Directory Open Access Journal |
| issn | 1738-3331 |
| language | English |
| last_indexed | 2024-03-12T01:08:26Z |
| publishDate | 2023-09-01 |
| publisher | Yong Chan Lee |
| record_format | Article |
| series | The Korean Journal of Helicobacter and Upper Gastrointestinal Research |
| spelling | doaj.art-0a631016ca8b45b3acaf2a49e0244b542023-09-14T07:45:58ZengYong Chan LeeThe Korean Journal of Helicobacter and Upper Gastrointestinal Research1738-33312023-09-0123315916610.7704/kjhugr.2023.0040788History and Pharmacological Mechanism of Gastric Acid-suppressive DrugsDong Han Yeom0Yong Sung Kim1Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, KoreaDigestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, KoreaGastric acid-related disorders are commonly encountered in clinical practice. Acetylcholine, gastrin, and histamine are physiological agonists that stimulate acid secretion from parietal cells. Histamine plays a decisive role in the transformation of parietal cells into acid-secreting forms. The H+, K+- ATPase proton pump, which represents the final step of acid secretion, translocates from cytoplasmic tubulovesicles to secretory canaliculi upon parietal cell stimulation and facilitates exchange of intracellular H+ with extracellular K+ in a 1:1 ratio. Histamine-2 receptor antagonists and proton pump inhibitors (PPIs) are widely used in clinical practice, and potassium-competitive acid blockers (P-CABs) have gained attention in recent times. P-CABs address the unmet needs of patients who receive conventional PPIs and have broadened the spectrum of drug choices; however, further research is warranted to confirm long-term safety of these drugs. Comprehensive understanding of the mechanisms of actions, characteristics, advantages and disadvantages, and the adverse effect profile is essential for appropriate prescription of gastric acid-suppressive drugs. In this review, we provide a developing history and outline the pharmacological mechanisms underlying various gastric acid-suppressive drugs used in clinical settings.http://www.helicojournal.org/upload/pdf/kjhugr-2023-0040.pdffexuprazanhistamine h2 antagonistsparietal cells, gastricproton pump inhibitorstegoprazan |
| spellingShingle | Dong Han Yeom Yong Sung Kim History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs The Korean Journal of Helicobacter and Upper Gastrointestinal Research fexuprazan histamine h2 antagonists parietal cells, gastric proton pump inhibitors tegoprazan |
| title | History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs |
| title_full | History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs |
| title_fullStr | History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs |
| title_full_unstemmed | History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs |
| title_short | History and Pharmacological Mechanism of Gastric Acid-suppressive Drugs |
| title_sort | history and pharmacological mechanism of gastric acid suppressive drugs |
| topic | fexuprazan histamine h2 antagonists parietal cells, gastric proton pump inhibitors tegoprazan |
| url | http://www.helicojournal.org/upload/pdf/kjhugr-2023-0040.pdf |
| work_keys_str_mv | AT donghanyeom historyandpharmacologicalmechanismofgastricacidsuppressivedrugs AT yongsungkim historyandpharmacologicalmechanismofgastricacidsuppressivedrugs |