Presence of human herpesvirus type 6, polyoma BK virus and parvovirus B19V in non-transplanted patients with hematological malignancies and neutropenic fever
Background: Febrile neutropenia is a common complication in adult patients undergoing chemotherapy for hematological malignancies. A potential causative agent is identified in approximately one third of the fever episodes. Objectives: We here investigated whether reactivated infection with human her...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Journal of Clinical Virology Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667038021000259 |
| _version_ | 1818727729011359744 |
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| author | Igge Gustafsson Carl Aust Zhibing Yun Kristina Broliden Lars Öhrmalm |
| author_facet | Igge Gustafsson Carl Aust Zhibing Yun Kristina Broliden Lars Öhrmalm |
| author_sort | Igge Gustafsson |
| collection | DOAJ |
| description | Background: Febrile neutropenia is a common complication in adult patients undergoing chemotherapy for hematological malignancies. A potential causative agent is identified in approximately one third of the fever episodes. Objectives: We here investigated whether reactivated infection with human herpes virus 6 (HHV-6), polyoma BK virus (BKV) and parvovirus B19 (B19V) is associated with this condition. Study Design: In a cross-sectional study, blood samples were collected at hospitalization of adult patients who developed neutropenic fever during chemotherapy for non-transplanted hematological malignancies. Detection of HHV-6A, HHV-6B, BKV and B19V DNA was performed by quantitative PCR. Clinical and laboratory data were extracted from medical records. Results: A total of 23 of 148 (16%) samples, representing 14 of 79 (18%) patients, were PCR positive for DNA representing at least one of the three viruses; HHV-6 (n = 7 samples), BKV (n = 16 samples) and B19V (n = 6 samples). None of the samples were positive for HHV-6A DNA and all B19V DNA positive samples had viral loads below 500 copies/mL. All fever episodes, with the exception of two episodes for one BKV DNA positive patient, presented alternative presumed causative agents of the fever as detected by routine clinical diagnostics. Levels of hemoglobin, leukocyte counts, neutrophil counts, electrolytes, and creatinine were comparable for fever episodes with and without detectable viral DNA. Conclusion: Although HHV-6B, BKV and B19V DNA could be detected in blood during a few neutropenic febrile episodes in non-transplanted hematological patients, the presence was not clearly associated to the fever. |
| first_indexed | 2024-12-17T22:18:43Z |
| format | Article |
| id | doaj.art-0a65538d19da493eb9181b53323a6270 |
| institution | Directory Open Access Journal |
| issn | 2667-0380 |
| language | English |
| last_indexed | 2024-12-17T22:18:43Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical Virology Plus |
| spelling | doaj.art-0a65538d19da493eb9181b53323a62702022-12-21T21:30:31ZengElsevierJournal of Clinical Virology Plus2667-03802021-09-0113100033Presence of human herpesvirus type 6, polyoma BK virus and parvovirus B19V in non-transplanted patients with hematological malignancies and neutropenic feverIgge Gustafsson0Carl Aust1Zhibing Yun2Kristina Broliden3Lars Öhrmalm4Department of Medicine Solna, Division of Infectious Diseases, Karolinska Institutet, Center for Molecular Medicine, Department of Infectious Diseases, Karolinska University Hospital, Stockholm 171 76, SwedenDepartment of Medicine Solna, Division of Infectious Diseases, Karolinska Institutet, Center for Molecular Medicine, Department of Infectious Diseases, Karolinska University Hospital, Stockholm 171 76, SwedenDepartment of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, SwedenDepartment of Medicine Solna, Division of Infectious Diseases, Karolinska Institutet, Center for Molecular Medicine, Department of Infectious Diseases, Karolinska University Hospital, Stockholm 171 76, Sweden; Corresponding author.Department of Medicine Solna, Division of Infectious Diseases, Karolinska Institutet, Center for Molecular Medicine, Department of Infectious Diseases, Karolinska University Hospital, Stockholm 171 76, SwedenBackground: Febrile neutropenia is a common complication in adult patients undergoing chemotherapy for hematological malignancies. A potential causative agent is identified in approximately one third of the fever episodes. Objectives: We here investigated whether reactivated infection with human herpes virus 6 (HHV-6), polyoma BK virus (BKV) and parvovirus B19 (B19V) is associated with this condition. Study Design: In a cross-sectional study, blood samples were collected at hospitalization of adult patients who developed neutropenic fever during chemotherapy for non-transplanted hematological malignancies. Detection of HHV-6A, HHV-6B, BKV and B19V DNA was performed by quantitative PCR. Clinical and laboratory data were extracted from medical records. Results: A total of 23 of 148 (16%) samples, representing 14 of 79 (18%) patients, were PCR positive for DNA representing at least one of the three viruses; HHV-6 (n = 7 samples), BKV (n = 16 samples) and B19V (n = 6 samples). None of the samples were positive for HHV-6A DNA and all B19V DNA positive samples had viral loads below 500 copies/mL. All fever episodes, with the exception of two episodes for one BKV DNA positive patient, presented alternative presumed causative agents of the fever as detected by routine clinical diagnostics. Levels of hemoglobin, leukocyte counts, neutrophil counts, electrolytes, and creatinine were comparable for fever episodes with and without detectable viral DNA. Conclusion: Although HHV-6B, BKV and B19V DNA could be detected in blood during a few neutropenic febrile episodes in non-transplanted hematological patients, the presence was not clearly associated to the fever.http://www.sciencedirect.com/science/article/pii/S2667038021000259Neutropenic feverBKVHHV6B19VDNAPCR |
| spellingShingle | Igge Gustafsson Carl Aust Zhibing Yun Kristina Broliden Lars Öhrmalm Presence of human herpesvirus type 6, polyoma BK virus and parvovirus B19V in non-transplanted patients with hematological malignancies and neutropenic fever Journal of Clinical Virology Plus Neutropenic fever BKV HHV6 B19V DNA PCR |
| title | Presence of human herpesvirus type 6, polyoma BK virus and parvovirus B19V in non-transplanted patients with hematological malignancies and neutropenic fever |
| title_full | Presence of human herpesvirus type 6, polyoma BK virus and parvovirus B19V in non-transplanted patients with hematological malignancies and neutropenic fever |
| title_fullStr | Presence of human herpesvirus type 6, polyoma BK virus and parvovirus B19V in non-transplanted patients with hematological malignancies and neutropenic fever |
| title_full_unstemmed | Presence of human herpesvirus type 6, polyoma BK virus and parvovirus B19V in non-transplanted patients with hematological malignancies and neutropenic fever |
| title_short | Presence of human herpesvirus type 6, polyoma BK virus and parvovirus B19V in non-transplanted patients with hematological malignancies and neutropenic fever |
| title_sort | presence of human herpesvirus type 6 polyoma bk virus and parvovirus b19v in non transplanted patients with hematological malignancies and neutropenic fever |
| topic | Neutropenic fever BKV HHV6 B19V DNA PCR |
| url | http://www.sciencedirect.com/science/article/pii/S2667038021000259 |
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