Expression and Impact of C1GalT1 in Cancer Development and Progression
C1GalT1 (T-synthase) is one of the key glycosyltransferases in the biosynthesis of O-linked mucin-type glycans of glycoproteins. It controls the formation of Core-1 disaccharide Galβ1,3GalNAcα- (Thomsen–Friedenreich oncofetal antigen, T or TF antigen) and Core-1-associated carbohydrate structures. R...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/24/6305 |
| _version_ | 1797506352367534080 |
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| author | Yangu Wan Lu-Gang Yu |
| author_facet | Yangu Wan Lu-Gang Yu |
| author_sort | Yangu Wan |
| collection | DOAJ |
| description | C1GalT1 (T-synthase) is one of the key glycosyltransferases in the biosynthesis of O-linked mucin-type glycans of glycoproteins. It controls the formation of Core-1 disaccharide Galβ1,3GalNAcα- (Thomsen–Friedenreich oncofetal antigen, T or TF antigen) and Core-1-associated carbohydrate structures. Recent studies have shown that C1GalT1 is overexpressed in many cancers of epithelial origin including colon, breast, gastric, head and neck, pancreatic, esophageal, prostate, and hepatocellular cancer. Overexpression of C1GalT1 is often seen to also be associated with poorer prognosis and poorer patient survival. Change of C1GalT1 expression causes glycosylation changes of many cell membrane glycoproteins including mucin proteins, growth factor receptors, adhesion molecules, and death receptors. This leads to alteration of the interactions of these cell surface molecules with their binding ligands, resulting in changes of cancer cell activity and behaviors. This review summarizes our current understanding of the expression of C1GalT1 in various cancers and discusses the impact of C1GalT change on cancer cell activities in cancer development and progression. |
| first_indexed | 2024-03-10T04:31:26Z |
| format | Article |
| id | doaj.art-0a68067d4d5b4ef4a3ec78e5a0805b65 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:31:26Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0a68067d4d5b4ef4a3ec78e5a0805b652023-11-23T04:06:48ZengMDPI AGCancers2072-66942021-12-011324630510.3390/cancers13246305Expression and Impact of C1GalT1 in Cancer Development and ProgressionYangu Wan0Lu-Gang Yu1Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GE, UKDepartment of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 3GE, UKC1GalT1 (T-synthase) is one of the key glycosyltransferases in the biosynthesis of O-linked mucin-type glycans of glycoproteins. It controls the formation of Core-1 disaccharide Galβ1,3GalNAcα- (Thomsen–Friedenreich oncofetal antigen, T or TF antigen) and Core-1-associated carbohydrate structures. Recent studies have shown that C1GalT1 is overexpressed in many cancers of epithelial origin including colon, breast, gastric, head and neck, pancreatic, esophageal, prostate, and hepatocellular cancer. Overexpression of C1GalT1 is often seen to also be associated with poorer prognosis and poorer patient survival. Change of C1GalT1 expression causes glycosylation changes of many cell membrane glycoproteins including mucin proteins, growth factor receptors, adhesion molecules, and death receptors. This leads to alteration of the interactions of these cell surface molecules with their binding ligands, resulting in changes of cancer cell activity and behaviors. This review summarizes our current understanding of the expression of C1GalT1 in various cancers and discusses the impact of C1GalT change on cancer cell activities in cancer development and progression.https://www.mdpi.com/2072-6694/13/24/6305C1GalT1T synthesisprotein glycosylationcancermucinTF antigen |
| spellingShingle | Yangu Wan Lu-Gang Yu Expression and Impact of C1GalT1 in Cancer Development and Progression Cancers C1GalT1 T synthesis protein glycosylation cancer mucin TF antigen |
| title | Expression and Impact of C1GalT1 in Cancer Development and Progression |
| title_full | Expression and Impact of C1GalT1 in Cancer Development and Progression |
| title_fullStr | Expression and Impact of C1GalT1 in Cancer Development and Progression |
| title_full_unstemmed | Expression and Impact of C1GalT1 in Cancer Development and Progression |
| title_short | Expression and Impact of C1GalT1 in Cancer Development and Progression |
| title_sort | expression and impact of c1galt1 in cancer development and progression |
| topic | C1GalT1 T synthesis protein glycosylation cancer mucin TF antigen |
| url | https://www.mdpi.com/2072-6694/13/24/6305 |
| work_keys_str_mv | AT yanguwan expressionandimpactofc1galt1incancerdevelopmentandprogression AT lugangyu expressionandimpactofc1galt1incancerdevelopmentandprogression |