Retrospective analysis of immunosuppression drug withdrawal after liver transplantation
Objective To analyze the clinical data of patients with immunosuppression drug withdrawal after liver transplantation. Methods The clinical data of 15 patients with immunosuppression drug withdrawal after liver transplantation in our center from January 2013 to June 2020 were analyzed retrospectivel...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Surgery Concepts & Practice
2021-05-01
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| Series: | Waike lilun yu shijian |
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| Online Access: | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1659481935490-1232223789.pdf |
| _version_ | 1827782483974815744 |
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| author | QI Debin, CHEN Peng, TONG Hui, PENG Chenghong, LI Tao |
| author_facet | QI Debin, CHEN Peng, TONG Hui, PENG Chenghong, LI Tao |
| author_sort | QI Debin, CHEN Peng, TONG Hui, PENG Chenghong, LI Tao |
| collection | DOAJ |
| description | Objective To analyze the clinical data of patients with immunosuppression drug withdrawal after liver transplantation. Methods The clinical data of 15 patients with immunosuppression drug withdrawal after liver transplantation in our center from January 2013 to June 2020 were analyzed retrospectively. Results Eleven patients had immunosuppression withdrawal passively with time(10.4±6.2) months because of severe adverse effects. Two cases had acute rejection and success rate was 81.8%. The withdrawal time of 4 patients with active immunosuppression withdrawal was (28.8±30.3) months, and withdrawal was all successful(100%). One case had complete immunosuppression withdrawn for 74 months. There were no statistically significant differences in terms of sex, age, body mass index, induction of monoclo-nal antibody, time after liver transplantation, complications(diabetes, hyperlipidemia, hypertension), withdrawal time and success rate between active withdrawal group and passive withdrawal group (P>0.05). Duration after liver transplantation in successful withdrawal group was significantly longer than that in failed withdrawal group(P<0.05). Conclusions The patients after liver transplantation with long-term survival can safely and completely withdraw immunosuppression under guidance by doctors, but should be followed up closely. |
| first_indexed | 2024-03-11T15:32:45Z |
| format | Article |
| id | doaj.art-0a683b4f7e9641aa9e9584f458472c00 |
| institution | Directory Open Access Journal |
| issn | 1007-9610 |
| language | zho |
| last_indexed | 2024-03-11T15:32:45Z |
| publishDate | 2021-05-01 |
| publisher | Editorial Office of Journal of Surgery Concepts & Practice |
| record_format | Article |
| series | Waike lilun yu shijian |
| spelling | doaj.art-0a683b4f7e9641aa9e9584f458472c002023-10-27T02:12:55ZzhoEditorial Office of Journal of Surgery Concepts & PracticeWaike lilun yu shijian1007-96102021-05-01260323123510.16139/j.1007-9610.2021.03.011Retrospective analysis of immunosuppression drug withdrawal after liver transplantationQI Debin, CHEN Peng, TONG Hui, PENG Chenghong, LI Tao0Liver Transplant Center, Department of Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaObjective To analyze the clinical data of patients with immunosuppression drug withdrawal after liver transplantation. Methods The clinical data of 15 patients with immunosuppression drug withdrawal after liver transplantation in our center from January 2013 to June 2020 were analyzed retrospectively. Results Eleven patients had immunosuppression withdrawal passively with time(10.4±6.2) months because of severe adverse effects. Two cases had acute rejection and success rate was 81.8%. The withdrawal time of 4 patients with active immunosuppression withdrawal was (28.8±30.3) months, and withdrawal was all successful(100%). One case had complete immunosuppression withdrawn for 74 months. There were no statistically significant differences in terms of sex, age, body mass index, induction of monoclo-nal antibody, time after liver transplantation, complications(diabetes, hyperlipidemia, hypertension), withdrawal time and success rate between active withdrawal group and passive withdrawal group (P>0.05). Duration after liver transplantation in successful withdrawal group was significantly longer than that in failed withdrawal group(P<0.05). Conclusions The patients after liver transplantation with long-term survival can safely and completely withdraw immunosuppression under guidance by doctors, but should be followed up closely.https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1659481935490-1232223789.pdf|liver transplantation|immunosuppression|withdrawl|immune tolerance |
| spellingShingle | QI Debin, CHEN Peng, TONG Hui, PENG Chenghong, LI Tao Retrospective analysis of immunosuppression drug withdrawal after liver transplantation Waike lilun yu shijian |liver transplantation|immunosuppression|withdrawl|immune tolerance |
| title | Retrospective analysis of immunosuppression drug withdrawal after liver transplantation |
| title_full | Retrospective analysis of immunosuppression drug withdrawal after liver transplantation |
| title_fullStr | Retrospective analysis of immunosuppression drug withdrawal after liver transplantation |
| title_full_unstemmed | Retrospective analysis of immunosuppression drug withdrawal after liver transplantation |
| title_short | Retrospective analysis of immunosuppression drug withdrawal after liver transplantation |
| title_sort | retrospective analysis of immunosuppression drug withdrawal after liver transplantation |
| topic | |liver transplantation|immunosuppression|withdrawl|immune tolerance |
| url | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1659481935490-1232223789.pdf |
| work_keys_str_mv | AT qidebinchenpengtonghuipengchenghonglitao retrospectiveanalysisofimmunosuppressiondrugwithdrawalafterlivertransplantation |