Erdheim-Chester Disease: Utility of 18F-FDG Positron Emission Tomography
Erdheim-Chester Disease (ECD) is a rare non Langerhans cell histiocytosis of unknown origin with multiorgan involvement. We report a case of a man who presented to us with haematuria, asthenia, fever, nausea and malleolar oedema. After computed tomography and magnetic resonance imaging, the patient...
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JCDR Research and Publications Private Limited
2018-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/11165/31708_CE(RA1)_F(T)_PF1_(EK_SL)_PFA(MJ_AnG)%20%20(2)_PN(SL).pdf |
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| author | Angelina Cistaro Maria Licari Simone Margotti Daniele Penna Vincenzo Arena |
| author_facet | Angelina Cistaro Maria Licari Simone Margotti Daniele Penna Vincenzo Arena |
| author_sort | Angelina Cistaro |
| collection | DOAJ |
| description | Erdheim-Chester Disease (ECD) is a rare non Langerhans cell histiocytosis of unknown origin with multiorgan involvement. We report a case of a man who presented to us with haematuria, asthenia, fever, nausea and malleolar oedema. After computed tomography and magnetic resonance imaging, the patient underwent a Positron Emission Tomography/Computed Tomography (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG) that revealed multiple focal uptake in the skeleton and also visceral and vascular involvement. After a retroperitoneal biopsy, diagnosis of ECD was made. The treatment begun with steroids and after one month, a second 18F-FDG PET/CT was performed, highlighting a partial response. After five months of specific treatment with inhibitors of tyrosine kinases, a third 18F-FDG PET/CT was done showing a complete response. The 18F-FDG PET/CT allows assessing the extent of involvement in ECD, to detect the most easily accessible sites for diagnostic biopsy and to monitor disease activity and response to consolidated and new therapies. |
| first_indexed | 2024-12-19T14:35:06Z |
| format | Article |
| id | doaj.art-0a6b93b781fd494595604d6cee5b973b |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-19T14:35:06Z |
| publishDate | 2018-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-0a6b93b781fd494595604d6cee5b973b2022-12-21T20:17:18ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-02-01122TD01TD0210.7860/JCDR/2018/31708.11165Erdheim-Chester Disease: Utility of 18F-FDG Positron Emission TomographyAngelina Cistaro0Maria Licari1Simone Margotti2Daniele Penna3Vincenzo Arena4Nuclear Physician, Coordinator of PET Paediatric AIMN Study InterGroup, Positron Emission Tomography Centre, IRMET, Affidea, Turin, Italy.Nuclear Physician, Department of Nuclear Medicine, ARNAS Civico Hospital, Palerm, Italy.Nuclear Physician, Positron Emission Tomography Centre, IRMET, Affidea, Turin, Italy.Nuclear Physician, Positron Emission Tomography Centre, IRMET, Affidea, Turin, Italy.Nuclear Physician, Positron Emission Tomography Centre, IRMET, Affidea, Turin, Italy.Erdheim-Chester Disease (ECD) is a rare non Langerhans cell histiocytosis of unknown origin with multiorgan involvement. We report a case of a man who presented to us with haematuria, asthenia, fever, nausea and malleolar oedema. After computed tomography and magnetic resonance imaging, the patient underwent a Positron Emission Tomography/Computed Tomography (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG) that revealed multiple focal uptake in the skeleton and also visceral and vascular involvement. After a retroperitoneal biopsy, diagnosis of ECD was made. The treatment begun with steroids and after one month, a second 18F-FDG PET/CT was performed, highlighting a partial response. After five months of specific treatment with inhibitors of tyrosine kinases, a third 18F-FDG PET/CT was done showing a complete response. The 18F-FDG PET/CT allows assessing the extent of involvement in ECD, to detect the most easily accessible sites for diagnostic biopsy and to monitor disease activity and response to consolidated and new therapies.https://jcdr.net/articles/PDF/11165/31708_CE(RA1)_F(T)_PF1_(EK_SL)_PFA(MJ_AnG)%20%20(2)_PN(SL).pdffluorodeoxyglucosenon langerhans cell histiocytosisvemurafenib |
| spellingShingle | Angelina Cistaro Maria Licari Simone Margotti Daniele Penna Vincenzo Arena Erdheim-Chester Disease: Utility of 18F-FDG Positron Emission Tomography Journal of Clinical and Diagnostic Research fluorodeoxyglucose non langerhans cell histiocytosis vemurafenib |
| title | Erdheim-Chester Disease: Utility of 18F-FDG Positron Emission Tomography |
| title_full | Erdheim-Chester Disease: Utility of 18F-FDG Positron Emission Tomography |
| title_fullStr | Erdheim-Chester Disease: Utility of 18F-FDG Positron Emission Tomography |
| title_full_unstemmed | Erdheim-Chester Disease: Utility of 18F-FDG Positron Emission Tomography |
| title_short | Erdheim-Chester Disease: Utility of 18F-FDG Positron Emission Tomography |
| title_sort | erdheim chester disease utility of 18f fdg positron emission tomography |
| topic | fluorodeoxyglucose non langerhans cell histiocytosis vemurafenib |
| url | https://jcdr.net/articles/PDF/11165/31708_CE(RA1)_F(T)_PF1_(EK_SL)_PFA(MJ_AnG)%20%20(2)_PN(SL).pdf |
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