Study of the Efficacy of PET/CT in Lung Aspiration Biopsy and Factors Associated with False-Negative Results
Purpose: We compared the outcomes of percutaneous transthoracic needle aspiration biopsy (PCNA) of lung masses in cases with and without prior positron emission tomography/computed tomography (PET/CT) information, and investigated the factors associated with false-negative pathological results. Ma...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Radiology
2018-09-01
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| Series: | 대한영상의학회지 |
| Subjects: | |
| Online Access: | https://doi.org/10.3348/jksr.2018.79.3.129 |
| _version_ | 1818503683246129152 |
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| author | Il Wan Son Ji Won Lee Yeon Joo Jeong Ahrong Kim Hie Bum Suh Geewon Lee |
| author_facet | Il Wan Son Ji Won Lee Yeon Joo Jeong Ahrong Kim Hie Bum Suh Geewon Lee |
| author_sort | Il Wan Son |
| collection | DOAJ |
| description | Purpose: We compared the outcomes of percutaneous transthoracic needle aspiration
biopsy (PCNA) of lung masses in cases with and without prior positron emission tomography/computed tomography (PET/CT) information, and investigated the factors associated with false-negative pathological results.
Materials and Methods: From a total of 291 patients, 161 underwent PCNA without
prior PET/CT imaging, while 130 underwent PET/CT before PCNA. Clinical characteristics, procedural variables, pathological results, and diagnostic success rates were
compared between the 2 groups. Among patients with initial negative (non-specific
benign) PCNA results, the radiological findings of these groups were compared to
evaluate the predictors of false-negative lesions.
Results: No significant difference was found in the clinical characteristics, procedural
characteristics, and pathological results of the 2 groups, nor was the diagnostic rate
significantly different between them (p = 0.818). Among patients with initial negative PCNA results, radiological characteristics were similar in both the groups. In multivariate analysis, the presence of necrosis (p = 0.005) and ground-glass opacity (GGO)
(p = 0.011) were the significant characteristics that indicated an increased probability
of initial false-negative results in PCNA.
Conclusion: Routine PET/CT did not have any additional benefit in patients undergoing PCNA of lung masses. The presence of necrosis or GGO could indicate an increased
probability of false-negative pathological results. |
| first_indexed | 2024-12-10T21:27:16Z |
| format | Article |
| id | doaj.art-0a6bad3f617f4f58921f2b769a6cd632 |
| institution | Directory Open Access Journal |
| issn | 1738-2637 2288-2928 |
| language | English |
| last_indexed | 2024-12-10T21:27:16Z |
| publishDate | 2018-09-01 |
| publisher | The Korean Society of Radiology |
| record_format | Article |
| series | 대한영상의학회지 |
| spelling | doaj.art-0a6bad3f617f4f58921f2b769a6cd6322022-12-22T01:32:57ZengThe Korean Society of Radiology대한영상의학회지1738-26372288-29282018-09-01793129138https://doi.org/10.3348/jksr.2018.79.3.129Study of the Efficacy of PET/CT in Lung Aspiration Biopsy and Factors Associated with False-Negative ResultsIl Wan Son0Ji Won Lee1Yeon Joo Jeong2Ahrong Kim3Hie Bum Suh4Geewon Lee5Department of Radiology, Pusan National University Hospital, Busan, KoreaDepartment of Radiology, Pusan National University Hospital, Busan, KoreaDepartment of Radiology, Pusan National University Hospital, Busan, KoreaDepartment of Pathology, Pusan National University Hospital, Busan, KoreaDepartment of Radiology, Pusan National University Hospital, Busan, KoreaDepartment of Radiology, Pusan National University Hospital, Busan, KoreaPurpose: We compared the outcomes of percutaneous transthoracic needle aspiration biopsy (PCNA) of lung masses in cases with and without prior positron emission tomography/computed tomography (PET/CT) information, and investigated the factors associated with false-negative pathological results. Materials and Methods: From a total of 291 patients, 161 underwent PCNA without prior PET/CT imaging, while 130 underwent PET/CT before PCNA. Clinical characteristics, procedural variables, pathological results, and diagnostic success rates were compared between the 2 groups. Among patients with initial negative (non-specific benign) PCNA results, the radiological findings of these groups were compared to evaluate the predictors of false-negative lesions. Results: No significant difference was found in the clinical characteristics, procedural characteristics, and pathological results of the 2 groups, nor was the diagnostic rate significantly different between them (p = 0.818). Among patients with initial negative PCNA results, radiological characteristics were similar in both the groups. In multivariate analysis, the presence of necrosis (p = 0.005) and ground-glass opacity (GGO) (p = 0.011) were the significant characteristics that indicated an increased probability of initial false-negative results in PCNA. Conclusion: Routine PET/CT did not have any additional benefit in patients undergoing PCNA of lung masses. The presence of necrosis or GGO could indicate an increased probability of false-negative pathological results.https://doi.org/10.3348/jksr.2018.79.3.129pet-ctlung neoplasmsmultidetector computed tomography |
| spellingShingle | Il Wan Son Ji Won Lee Yeon Joo Jeong Ahrong Kim Hie Bum Suh Geewon Lee Study of the Efficacy of PET/CT in Lung Aspiration Biopsy and Factors Associated with False-Negative Results 대한영상의학회지 pet-ct lung neoplasms multidetector computed tomography |
| title | Study of the Efficacy of PET/CT in Lung Aspiration Biopsy and Factors Associated with False-Negative Results |
| title_full | Study of the Efficacy of PET/CT in Lung Aspiration Biopsy and Factors Associated with False-Negative Results |
| title_fullStr | Study of the Efficacy of PET/CT in Lung Aspiration Biopsy and Factors Associated with False-Negative Results |
| title_full_unstemmed | Study of the Efficacy of PET/CT in Lung Aspiration Biopsy and Factors Associated with False-Negative Results |
| title_short | Study of the Efficacy of PET/CT in Lung Aspiration Biopsy and Factors Associated with False-Negative Results |
| title_sort | study of the efficacy of pet ct in lung aspiration biopsy and factors associated with false negative results |
| topic | pet-ct lung neoplasms multidetector computed tomography |
| url | https://doi.org/10.3348/jksr.2018.79.3.129 |
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