Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis

Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis

Diosgenin, a natural product with steroidal structure, has a wide range of clinical applications in China. It also shows great potential in the treatment of blood clots and nerve damage. To enhance the bioavailability as well as efficacy of diosgenin, eighteen diosgenin-amino acid derivatives were d...

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Bibliographic Details
Main Authors: Desheng Cai, Jinchai Qi, Yuqin Yang, Wenxi Zhang, Fei Zhou, Xiaohui Jia, Wenbo Guo, Xuemei Huang, Feng Gao, Hongshan Chen, Tong Li, Guoping Li, Penglong Wang, Yuzhong Zhang, Haimin Lei
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Molecules
Subjects:
diosgenin-amino acids derivatives
neuroprotection
angiogenesis
cam model
Online Access:https://www.mdpi.com/1420-3049/24/22/4025

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