Exercise-Induced Bronchoconstriction Identified Using the Forced Oscillation Technique
Objective: Lung mechanics using the forced oscillation technique (FOT) is suggested to be equivalent and more sensitive in determining exercise-induced bronchoconstriction (EIB) than spirometry. Dynamic alterations in minute ventilation (VE) may affect this measurement. We investigated changes in FO...
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| Format: | Article |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.01411/full |
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| author | Leigh M. Seccombe Leigh M. Seccombe Matthew J. Peters Matthew J. Peters Lachlan Buddle Claude S. Farah Claude S. Farah Claude S. Farah |
| author_facet | Leigh M. Seccombe Leigh M. Seccombe Matthew J. Peters Matthew J. Peters Lachlan Buddle Claude S. Farah Claude S. Farah Claude S. Farah |
| author_sort | Leigh M. Seccombe |
| collection | DOAJ |
| description | Objective: Lung mechanics using the forced oscillation technique (FOT) is suggested to be equivalent and more sensitive in determining exercise-induced bronchoconstriction (EIB) than spirometry. Dynamic alterations in minute ventilation (VE) may affect this measurement. We investigated changes in FOT parameters post exercise challenge (EC) in people with asthma as compared to spirometry. The rate of recovery and any effect of raised VE following exercise on FOT parameters were also assessed.Method: Airway resistance (R5) and reactance (X5) at 5 Hz and VE were measured prior to forced expiratory volume in 1 s (FEV1) before and up to 20 min after a standard EC in people with asthma and healthy controls. Airway hyperresponsiveness to the hyperosmolar mannitol test was measured in the asthmatic subjects within 1 week of the EC. Baseline and sequential measures were assessed using repeated measures ANOVA and Pearson’s correlation. Group demographics and recovery data were compared using an unpaired t test.Results: Subjects with current asthma (n = 19, mean ± SD age 28 ± 6 years) and controls (n = 10, 31 ± 5 years) were studied. Baseline FEV1, R5, X5, and VE were similar between groups (p > 0.09). Airway hyperresponsiveness was present in 12/19 asthmatic subjects. The EC max % change of R5 and X5 correlated with FEV1 (r > 0.90) and were only different to controls in those with asthma that responded by FEV1 criteria (p < 0.01). EC recovery of R5 was similar to FEV1; however, X5 was greater (p = 0.03). Elevated VE post EC did not affect the % change in FOT parameters across all subjects (p > 0.3). R5 and X5 were highly sensitive in determining a positive EC response (80–86%), but X5 was more specific (93 vs. 80%).Conclusion: FOT parameters tracked with forced maneuvers and were not influenced by increased ventilation following an exercise challenge designed to elicit EIB. FOT identified EIB similarly to spirometry in patients with asthma. |
| first_indexed | 2024-12-12T01:24:26Z |
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| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T01:24:26Z |
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| spelling | doaj.art-0a6d5009cfbd489e935faf9b122250da2022-12-22T00:43:08ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-11-011010.3389/fphys.2019.01411484433Exercise-Induced Bronchoconstriction Identified Using the Forced Oscillation TechniqueLeigh M. Seccombe0Leigh M. Seccombe1Matthew J. Peters2Matthew J. Peters3Lachlan Buddle4Claude S. Farah5Claude S. Farah6Claude S. Farah7Thoracic Medicine, Concord Hospital, Sydney, NSW, AustraliaFaculty of Medicine and Health, Sydney University, Camperdown, NSW, AustraliaThoracic Medicine, Concord Hospital, Sydney, NSW, AustraliaFaculty of Medicine and Health, Sydney University, Camperdown, NSW, AustraliaThoracic Medicine, Concord Hospital, Sydney, NSW, AustraliaThoracic Medicine, Concord Hospital, Sydney, NSW, AustraliaFaculty of Medicine and Health, Sydney University, Camperdown, NSW, AustraliaThe Woolcock Institute of Medical Research, Sydney, NSW, AustraliaObjective: Lung mechanics using the forced oscillation technique (FOT) is suggested to be equivalent and more sensitive in determining exercise-induced bronchoconstriction (EIB) than spirometry. Dynamic alterations in minute ventilation (VE) may affect this measurement. We investigated changes in FOT parameters post exercise challenge (EC) in people with asthma as compared to spirometry. The rate of recovery and any effect of raised VE following exercise on FOT parameters were also assessed.Method: Airway resistance (R5) and reactance (X5) at 5 Hz and VE were measured prior to forced expiratory volume in 1 s (FEV1) before and up to 20 min after a standard EC in people with asthma and healthy controls. Airway hyperresponsiveness to the hyperosmolar mannitol test was measured in the asthmatic subjects within 1 week of the EC. Baseline and sequential measures were assessed using repeated measures ANOVA and Pearson’s correlation. Group demographics and recovery data were compared using an unpaired t test.Results: Subjects with current asthma (n = 19, mean ± SD age 28 ± 6 years) and controls (n = 10, 31 ± 5 years) were studied. Baseline FEV1, R5, X5, and VE were similar between groups (p > 0.09). Airway hyperresponsiveness was present in 12/19 asthmatic subjects. The EC max % change of R5 and X5 correlated with FEV1 (r > 0.90) and were only different to controls in those with asthma that responded by FEV1 criteria (p < 0.01). EC recovery of R5 was similar to FEV1; however, X5 was greater (p = 0.03). Elevated VE post EC did not affect the % change in FOT parameters across all subjects (p > 0.3). R5 and X5 were highly sensitive in determining a positive EC response (80–86%), but X5 was more specific (93 vs. 80%).Conclusion: FOT parameters tracked with forced maneuvers and were not influenced by increased ventilation following an exercise challenge designed to elicit EIB. FOT identified EIB similarly to spirometry in patients with asthma.https://www.frontiersin.org/article/10.3389/fphys.2019.01411/fullairway resistanceexercise-induced bronchoconstrictionairway reactanceasthmarespiratory function |
| spellingShingle | Leigh M. Seccombe Leigh M. Seccombe Matthew J. Peters Matthew J. Peters Lachlan Buddle Claude S. Farah Claude S. Farah Claude S. Farah Exercise-Induced Bronchoconstriction Identified Using the Forced Oscillation Technique Frontiers in Physiology airway resistance exercise-induced bronchoconstriction airway reactance asthma respiratory function |
| title | Exercise-Induced Bronchoconstriction Identified Using the Forced Oscillation Technique |
| title_full | Exercise-Induced Bronchoconstriction Identified Using the Forced Oscillation Technique |
| title_fullStr | Exercise-Induced Bronchoconstriction Identified Using the Forced Oscillation Technique |
| title_full_unstemmed | Exercise-Induced Bronchoconstriction Identified Using the Forced Oscillation Technique |
| title_short | Exercise-Induced Bronchoconstriction Identified Using the Forced Oscillation Technique |
| title_sort | exercise induced bronchoconstriction identified using the forced oscillation technique |
| topic | airway resistance exercise-induced bronchoconstriction airway reactance asthma respiratory function |
| url | https://www.frontiersin.org/article/10.3389/fphys.2019.01411/full |
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