CA-125 and CCL2 may indicate inflammation in peritoneal dialysis patients
Abstract Introduction: Progressive structural changes in the peritoneal membrane occur over the course of treatment in peritoneal dialysis (PD), resulting in an increase in cytokines such as CCL2 and structural changes in peritoneal membrane triggering an increase in CA-125 in dialysate, which refl...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Nefrologia
2021-05-01
|
| Series: | Brazilian Journal of Nephrology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002021000400502&tlng=en |
| _version_ | 1818745173888204800 |
|---|---|
| author | Wander Valadares de Oliveira Júnior Sylvia Dias Turani Maria Aparecida Silva Marinho Sérgio Wyton Lima Pinto Alba Otoni Roberta Carvalho Figueiredo Danyelle Romana Alves Rios |
| author_facet | Wander Valadares de Oliveira Júnior Sylvia Dias Turani Maria Aparecida Silva Marinho Sérgio Wyton Lima Pinto Alba Otoni Roberta Carvalho Figueiredo Danyelle Romana Alves Rios |
| author_sort | Wander Valadares de Oliveira Júnior |
| collection | DOAJ |
| description | Abstract Introduction: Progressive structural changes in the peritoneal membrane occur over the course of treatment in peritoneal dialysis (PD), resulting in an increase in cytokines such as CCL2 and structural changes in peritoneal membrane triggering an increase in CA-125 in dialysate, which reflects a probable local inflammatory process, with possible loss of mesothelial cells. Thus, the current study aimed to evaluate the association between plasma and CCL2 and CA-125 dialysate levels in patients undergoing PD. Methods: Cross-sectional study was conducted with 41 patients undergoing PD. The assessments of CA-125 and CCL2 levels were performed using a capture ELISA. Correlations were estimated using Spearman's correlation and the investigation of the association between the explanatory variables (CCL2) and response variable (CA-125) was done for crude ratio of arithmetic means and adjusted utilizing generalized linear models. Results: A moderate positive correlation was observed between the levels of CA-125 and CCL2 in the dialysate (rho = 0.696). A statistically significant association was found between the levels in the CCL2 and CA-125 dialysate (RoM=1.31; CI = 1.20-1.43), which remained after adjustment for age (RoM = 1.31; CI=1.19-1.44) and for time in months of PD (RoM=1.34, CI=1.22-1.48). Conclusion: The association of CA-125 levels with CCL2 in the dialysate may indicate that the local inflammatory process leads to temporary or definitive changes in peritoneal membrane. A better understanding of this pathogenesis could contribute to the discovery of new inflammatory biomarkers. |
| first_indexed | 2024-12-18T02:56:00Z |
| format | Article |
| id | doaj.art-0a6e02017cd447cea1d16f6338ecf030 |
| institution | Directory Open Access Journal |
| issn | 2175-8239 |
| language | English |
| last_indexed | 2024-12-18T02:56:00Z |
| publishDate | 2021-05-01 |
| publisher | Sociedade Brasileira de Nefrologia |
| record_format | Article |
| series | Brazilian Journal of Nephrology |
| spelling | doaj.art-0a6e02017cd447cea1d16f6338ecf0302022-12-21T21:23:22ZengSociedade Brasileira de NefrologiaBrazilian Journal of Nephrology2175-82392021-05-0143450250910.1590/2175-8239-jbn-2020-0255CA-125 and CCL2 may indicate inflammation in peritoneal dialysis patientsWander Valadares de Oliveira Júniorhttps://orcid.org/0000-0003-3209-9386Sylvia Dias Turanihttps://orcid.org/0000-0002-2055-185XMaria Aparecida Silva MarinhoSérgio Wyton Lima Pintohttps://orcid.org/0000-0001-7239-0413Alba OtoniRoberta Carvalho Figueiredohttps://orcid.org/0000-0001-6462-3504Danyelle Romana Alves Rioshttps://orcid.org/0000-0001-6377-241XAbstract Introduction: Progressive structural changes in the peritoneal membrane occur over the course of treatment in peritoneal dialysis (PD), resulting in an increase in cytokines such as CCL2 and structural changes in peritoneal membrane triggering an increase in CA-125 in dialysate, which reflects a probable local inflammatory process, with possible loss of mesothelial cells. Thus, the current study aimed to evaluate the association between plasma and CCL2 and CA-125 dialysate levels in patients undergoing PD. Methods: Cross-sectional study was conducted with 41 patients undergoing PD. The assessments of CA-125 and CCL2 levels were performed using a capture ELISA. Correlations were estimated using Spearman's correlation and the investigation of the association between the explanatory variables (CCL2) and response variable (CA-125) was done for crude ratio of arithmetic means and adjusted utilizing generalized linear models. Results: A moderate positive correlation was observed between the levels of CA-125 and CCL2 in the dialysate (rho = 0.696). A statistically significant association was found between the levels in the CCL2 and CA-125 dialysate (RoM=1.31; CI = 1.20-1.43), which remained after adjustment for age (RoM = 1.31; CI=1.19-1.44) and for time in months of PD (RoM=1.34, CI=1.22-1.48). Conclusion: The association of CA-125 levels with CCL2 in the dialysate may indicate that the local inflammatory process leads to temporary or definitive changes in peritoneal membrane. A better understanding of this pathogenesis could contribute to the discovery of new inflammatory biomarkers.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002021000400502&tlng=enPeritoneal DialysisCA-125 AntigenChemokine CCL2Chronic Kidney DiseaseInflammation |
| spellingShingle | Wander Valadares de Oliveira Júnior Sylvia Dias Turani Maria Aparecida Silva Marinho Sérgio Wyton Lima Pinto Alba Otoni Roberta Carvalho Figueiredo Danyelle Romana Alves Rios CA-125 and CCL2 may indicate inflammation in peritoneal dialysis patients Brazilian Journal of Nephrology Peritoneal Dialysis CA-125 Antigen Chemokine CCL2 Chronic Kidney Disease Inflammation |
| title | CA-125 and CCL2 may indicate inflammation in peritoneal dialysis patients |
| title_full | CA-125 and CCL2 may indicate inflammation in peritoneal dialysis patients |
| title_fullStr | CA-125 and CCL2 may indicate inflammation in peritoneal dialysis patients |
| title_full_unstemmed | CA-125 and CCL2 may indicate inflammation in peritoneal dialysis patients |
| title_short | CA-125 and CCL2 may indicate inflammation in peritoneal dialysis patients |
| title_sort | ca 125 and ccl2 may indicate inflammation in peritoneal dialysis patients |
| topic | Peritoneal Dialysis CA-125 Antigen Chemokine CCL2 Chronic Kidney Disease Inflammation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-28002021000400502&tlng=en |
| work_keys_str_mv | AT wandervaladaresdeoliveirajunior ca125andccl2mayindicateinflammationinperitonealdialysispatients AT sylviadiasturani ca125andccl2mayindicateinflammationinperitonealdialysispatients AT mariaaparecidasilvamarinho ca125andccl2mayindicateinflammationinperitonealdialysispatients AT sergiowytonlimapinto ca125andccl2mayindicateinflammationinperitonealdialysispatients AT albaotoni ca125andccl2mayindicateinflammationinperitonealdialysispatients AT robertacarvalhofigueiredo ca125andccl2mayindicateinflammationinperitonealdialysispatients AT danyelleromanaalvesrios ca125andccl2mayindicateinflammationinperitonealdialysispatients |