Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin
Abstract The development of nanomaterials for delivering natural compounds has emerged as a promising approach for atherosclerosis therapy. However, premature drug release remains a challenge. Here, we present a ROS-responsive biomimetic nanocomplex co-loaded with Geniposide (GP) and Emodin (EM) in...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-024-02389-5 |
| _version_ | 1797233227932368896 |
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| author | Zhenxian Li Haimei Zhu Hao Liu Dayue Liu Jianhe Liu Yi Zhang Zhang Qin Yijia Xu Yuan Peng Lihua Ruan Jintao Li Yao He Bin Liu Yun Long |
| author_facet | Zhenxian Li Haimei Zhu Hao Liu Dayue Liu Jianhe Liu Yi Zhang Zhang Qin Yijia Xu Yuan Peng Lihua Ruan Jintao Li Yao He Bin Liu Yun Long |
| author_sort | Zhenxian Li |
| collection | DOAJ |
| description | Abstract The development of nanomaterials for delivering natural compounds has emerged as a promising approach for atherosclerosis therapy. However, premature drug release remains a challenge. Here, we present a ROS-responsive biomimetic nanocomplex co-loaded with Geniposide (GP) and Emodin (EM) in nanoliposome particles (LP NPs) for targeted atherosclerosis therapy. The nanocomplex, hybridized with the macrophage membrane (Møm), effectively evades immune system clearance and targets atherosclerotic plaques. A modified thioketal (TK) system responds to ROS-rich plaque regions, triggering controlled drug release. In vitro, the nanocomplex inhibits endothelial cell apoptosis and macrophage lipid accumulation, restores endothelial cell function, and promotes cholesterol effluxion. In vivo, it targets ROS-rich atherosclerotic plaques, reducing plaque area ROS levels and restoring endothelial cell function, consequently promoting cholesterol outflow. Our study demonstrates that ROS-responsive biomimetic nanocomplexes co-delivering GP and EM exert a synergistic effect against endothelial cell apoptosis and lipid deposition in macrophages, offering a promising dual-cell therapy modality for atherosclerosis regression. |
| first_indexed | 2024-04-24T16:12:50Z |
| format | Article |
| id | doaj.art-0a6ebb65d17f464c99d67c28d8174755 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-24T16:12:50Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-0a6ebb65d17f464c99d67c28d81747552024-03-31T11:34:04ZengBMCJournal of Nanobiotechnology1477-31552024-03-0122112010.1186/s12951-024-02389-5Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and EmodinZhenxian Li0Haimei Zhu1Hao Liu2Dayue Liu3Jianhe Liu4Yi Zhang5Zhang Qin6Yijia Xu7Yuan Peng8Lihua Ruan9Jintao Li10Yao He11Bin Liu12Yun Long13Department of Cardiology, The First Hospital of Hunan University of Chinese MedicineDepartment of Pain, The First Hospital of Hunan University of Chinese MedicineDepartment of Rehabilitation, The Second Xiangya Hospital, Central South UniversityNHC Key Laboratory of Metabolic Cardiovascular Diseases Research, Ningxia Medical UniversityDepartment of Cardiology, The First Hospital of Hunan University of Chinese MedicineDepartment of Cardiology, The First Hospital of Hunan University of Chinese MedicineDepartment of Cardiology, The First Hospital of Hunan University of Chinese MedicineDepartment of Cardiology, The First Hospital of Hunan University of Chinese MedicineDepartment of Cardiology, The First Hospital of Hunan University of Chinese MedicineDepartment of Cardiology, The First Hospital of Hunan University of Chinese MedicineDepartment of Cardiology, The First Hospital of Hunan University of Chinese MedicineDepartment of Cardiology, The First Hospital of Hunan University of Chinese MedicineCollege of Biology, Hunan UniversityDepartment of Cardiology, The First Hospital of Hunan University of Chinese MedicineAbstract The development of nanomaterials for delivering natural compounds has emerged as a promising approach for atherosclerosis therapy. However, premature drug release remains a challenge. Here, we present a ROS-responsive biomimetic nanocomplex co-loaded with Geniposide (GP) and Emodin (EM) in nanoliposome particles (LP NPs) for targeted atherosclerosis therapy. The nanocomplex, hybridized with the macrophage membrane (Møm), effectively evades immune system clearance and targets atherosclerotic plaques. A modified thioketal (TK) system responds to ROS-rich plaque regions, triggering controlled drug release. In vitro, the nanocomplex inhibits endothelial cell apoptosis and macrophage lipid accumulation, restores endothelial cell function, and promotes cholesterol effluxion. In vivo, it targets ROS-rich atherosclerotic plaques, reducing plaque area ROS levels and restoring endothelial cell function, consequently promoting cholesterol outflow. Our study demonstrates that ROS-responsive biomimetic nanocomplexes co-delivering GP and EM exert a synergistic effect against endothelial cell apoptosis and lipid deposition in macrophages, offering a promising dual-cell therapy modality for atherosclerosis regression.https://doi.org/10.1186/s12951-024-02389-5AtherosclerosisROS-responsiveBiomimetic liposomeGeniposideEmodin |
| spellingShingle | Zhenxian Li Haimei Zhu Hao Liu Dayue Liu Jianhe Liu Yi Zhang Zhang Qin Yijia Xu Yuan Peng Lihua Ruan Jintao Li Yao He Bin Liu Yun Long Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin Journal of Nanobiotechnology Atherosclerosis ROS-responsive Biomimetic liposome Geniposide Emodin |
| title | Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin |
| title_full | Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin |
| title_fullStr | Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin |
| title_full_unstemmed | Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin |
| title_short | Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin |
| title_sort | synergistic dual cell therapy for atherosclerosis regression ros responsive bio liposomes co loaded with geniposide and emodin |
| topic | Atherosclerosis ROS-responsive Biomimetic liposome Geniposide Emodin |
| url | https://doi.org/10.1186/s12951-024-02389-5 |
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