Microbiological and host features associated with corynebacteriosis in cancer patients: a five-year study
During a five-year period, 932 clinical isolates from cancer patients treated in a Brazilian reference centre were identified as corynebacteria; 86% of the cultures came from patients who had been clinically and microbiologically classified as infected and 77.1% of these patients had been hospitalis...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2009-09-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000600015 |
| _version_ | 1797715755971641344 |
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| author | CAS Martins LMD Faria MC Souza TCF Camello E Velasco R Hirata Jr LCS Thuler AL Mattos-Guaraldi |
| author_facet | CAS Martins LMD Faria MC Souza TCF Camello E Velasco R Hirata Jr LCS Thuler AL Mattos-Guaraldi |
| author_sort | CAS Martins |
| collection | DOAJ |
| description | During a five-year period, 932 clinical isolates from cancer patients treated in a Brazilian reference centre were identified as corynebacteria; 86% of the cultures came from patients who had been clinically and microbiologically classified as infected and 77.1% of these patients had been hospitalised (71.1% from surgical wards). The adult solid tumour was the most common underlying malignant disease (66.7%). The univariate and multivariate analyses showed that hospitalised patients had a six-fold greater risk (OR = 5.5, 95% CI = 1.15-26.30 p = 0.033) related to 30-day mortality. The predominant species were Corynebacterium amycolatum (44.7%), Corynebacterium minutissimum (18.3%) and Corynebacterium pseudodiphtheriticum (8.5%). The upper urinary tracts, surgical wounds, lower respiratory tracts, ulcerated tumours and indwelling venous catheters were the most frequent sources of C. amycolatum strains. Corynebacterium jeikeium infection occurred primarily in neutropenic patients who have used venous catheters, while infection caused by C. amycolatum and other species emerged mainly in patients with solid tumours. |
| first_indexed | 2024-03-12T08:11:27Z |
| format | Article |
| id | doaj.art-0a6f474538f44c549a67f25d2a7a653b |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:11:27Z |
| publishDate | 2009-09-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-0a6f474538f44c549a67f25d2a7a653b2023-09-02T19:06:41ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602009-09-01104690591310.1590/S0074-02762009000600015Microbiological and host features associated with corynebacteriosis in cancer patients: a five-year studyCAS MartinsLMD FariaMC SouzaTCF CamelloE VelascoR Hirata JrLCS ThulerAL Mattos-GuaraldiDuring a five-year period, 932 clinical isolates from cancer patients treated in a Brazilian reference centre were identified as corynebacteria; 86% of the cultures came from patients who had been clinically and microbiologically classified as infected and 77.1% of these patients had been hospitalised (71.1% from surgical wards). The adult solid tumour was the most common underlying malignant disease (66.7%). The univariate and multivariate analyses showed that hospitalised patients had a six-fold greater risk (OR = 5.5, 95% CI = 1.15-26.30 p = 0.033) related to 30-day mortality. The predominant species were Corynebacterium amycolatum (44.7%), Corynebacterium minutissimum (18.3%) and Corynebacterium pseudodiphtheriticum (8.5%). The upper urinary tracts, surgical wounds, lower respiratory tracts, ulcerated tumours and indwelling venous catheters were the most frequent sources of C. amycolatum strains. Corynebacterium jeikeium infection occurred primarily in neutropenic patients who have used venous catheters, while infection caused by C. amycolatum and other species emerged mainly in patients with solid tumours.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000600015Corynebacterium amycolatumCorynebacterium infectioncancer |
| spellingShingle | CAS Martins LMD Faria MC Souza TCF Camello E Velasco R Hirata Jr LCS Thuler AL Mattos-Guaraldi Microbiological and host features associated with corynebacteriosis in cancer patients: a five-year study Memorias do Instituto Oswaldo Cruz Corynebacterium amycolatum Corynebacterium infection cancer |
| title | Microbiological and host features associated with corynebacteriosis in cancer patients: a five-year study |
| title_full | Microbiological and host features associated with corynebacteriosis in cancer patients: a five-year study |
| title_fullStr | Microbiological and host features associated with corynebacteriosis in cancer patients: a five-year study |
| title_full_unstemmed | Microbiological and host features associated with corynebacteriosis in cancer patients: a five-year study |
| title_short | Microbiological and host features associated with corynebacteriosis in cancer patients: a five-year study |
| title_sort | microbiological and host features associated with corynebacteriosis in cancer patients a five year study |
| topic | Corynebacterium amycolatum Corynebacterium infection cancer |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000600015 |
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