Recent advances in polymeric biomaterials-based gene delivery for cartilage repair
Untreated articular cartilage damage normally results in osteoarthritis and even disability that affects millions of people. However, both the existing surgical treatment and tissue engineering approaches are unable to regenerate the original structures of articular cartilage durably, and new strate...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2020-12-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X20300955 |
| _version_ | 1797203207555907584 |
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| author | Ran Yang Fei Chen Jinshan Guo Dongfang Zhou Shifang Luan |
| author_facet | Ran Yang Fei Chen Jinshan Guo Dongfang Zhou Shifang Luan |
| author_sort | Ran Yang |
| collection | DOAJ |
| description | Untreated articular cartilage damage normally results in osteoarthritis and even disability that affects millions of people. However, both the existing surgical treatment and tissue engineering approaches are unable to regenerate the original structures of articular cartilage durably, and new strategies for integrative cartilage repair are needed. Gene therapy provides local production of therapeutic factors, especially guided by biomaterials can minimize the diffusion and loss of the genes or gene complexes, achieve accurate spatiotemporally release of gene products, thus provideing long-term treatment for cartilage repair. The widespread application of gene therapy requires the development of safe and effective gene delivery vectors and supportive gene-activated matrices. Among them, polymeric biomaterials are particularly attractive due to their tunable physiochemical properties, as well as excellent adaptive performance. This paper reviews the recent advances in polymeric biomaterial-guided gene delivery for cartilage repair, with an emphasis on the important role of polymeric biomaterials in delivery systems. |
| first_indexed | 2024-04-24T08:15:40Z |
| format | Article |
| id | doaj.art-0a702d8642ec47f3afc2a72d1182bdb8 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:15:40Z |
| publishDate | 2020-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-0a702d8642ec47f3afc2a72d1182bdb82024-04-17T03:31:05ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2020-12-01549901003Recent advances in polymeric biomaterials-based gene delivery for cartilage repairRan Yang0Fei Chen1Jinshan Guo2Dongfang Zhou3Shifang Luan4State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China; School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China; College of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, PR ChinaCenter for Materials Synthetic Biology, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, PR ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, PR ChinaSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China; Corresponding author. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, PR China.State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China; College of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, PR China; Corresponding author. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.Untreated articular cartilage damage normally results in osteoarthritis and even disability that affects millions of people. However, both the existing surgical treatment and tissue engineering approaches are unable to regenerate the original structures of articular cartilage durably, and new strategies for integrative cartilage repair are needed. Gene therapy provides local production of therapeutic factors, especially guided by biomaterials can minimize the diffusion and loss of the genes or gene complexes, achieve accurate spatiotemporally release of gene products, thus provideing long-term treatment for cartilage repair. The widespread application of gene therapy requires the development of safe and effective gene delivery vectors and supportive gene-activated matrices. Among them, polymeric biomaterials are particularly attractive due to their tunable physiochemical properties, as well as excellent adaptive performance. This paper reviews the recent advances in polymeric biomaterial-guided gene delivery for cartilage repair, with an emphasis on the important role of polymeric biomaterials in delivery systems.http://www.sciencedirect.com/science/article/pii/S2452199X20300955Cartilage repairGene therapyPolymeric biomaterialsDelivery vectorsGene-activated matrices |
| spellingShingle | Ran Yang Fei Chen Jinshan Guo Dongfang Zhou Shifang Luan Recent advances in polymeric biomaterials-based gene delivery for cartilage repair Bioactive Materials Cartilage repair Gene therapy Polymeric biomaterials Delivery vectors Gene-activated matrices |
| title | Recent advances in polymeric biomaterials-based gene delivery for cartilage repair |
| title_full | Recent advances in polymeric biomaterials-based gene delivery for cartilage repair |
| title_fullStr | Recent advances in polymeric biomaterials-based gene delivery for cartilage repair |
| title_full_unstemmed | Recent advances in polymeric biomaterials-based gene delivery for cartilage repair |
| title_short | Recent advances in polymeric biomaterials-based gene delivery for cartilage repair |
| title_sort | recent advances in polymeric biomaterials based gene delivery for cartilage repair |
| topic | Cartilage repair Gene therapy Polymeric biomaterials Delivery vectors Gene-activated matrices |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X20300955 |
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