Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats
Oxaliplatin is a key drug used in the management of solid tumors, such as colorectal cancer; however, it causes peripheral neuropathy. In this study, we investigated the effect of ibudilast, a phosphodiesterase inhibitor, on oxaliplatin-induced mechanical allodynia and histological changes in rats....
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Journal of Pharmacological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861321000608 |
| _version_ | 1819152591863414784 |
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| author | Nobuaki Egashira Yu Goto Ryota Takahashi Hikari Iba Shota Yamamoto Takuya Watanabe Kaori Kubota Takehiro Kawashiri Chise Taniguchi Shutaro Katsurabayashi Katsunori Iwasaki |
| author_facet | Nobuaki Egashira Yu Goto Ryota Takahashi Hikari Iba Shota Yamamoto Takuya Watanabe Kaori Kubota Takehiro Kawashiri Chise Taniguchi Shutaro Katsurabayashi Katsunori Iwasaki |
| author_sort | Nobuaki Egashira |
| collection | DOAJ |
| description | Oxaliplatin is a key drug used in the management of solid tumors, such as colorectal cancer; however, it causes peripheral neuropathy. In this study, we investigated the effect of ibudilast, a phosphodiesterase inhibitor, on oxaliplatin-induced mechanical allodynia and histological changes in rats. Ibudilast (7.5 mg/kg, i.p., 5 times per week) reduced mechanical allodynia and histological changes induced by oxaliplatin (4 mg/kg, i.p., twice a week). In contrast, ibudilast (0.01–10 μM) had no effect on oxaliplatin-induced tumor cytotoxicity in murine colon adenocarcinoma 26 cells. These findings suggest that ibudilast could be useful for preventing oxaliplatin-induced peripheral neuropathy in clinical settings. |
| first_indexed | 2024-12-22T14:51:44Z |
| format | Article |
| id | doaj.art-0a7262820c5a46f095577221d18b3940 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-22T14:51:44Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-0a7262820c5a46f095577221d18b39402022-12-21T18:22:18ZengElsevierJournal of Pharmacological Sciences1347-86132021-09-011471114117Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in ratsNobuaki Egashira0Yu Goto1Ryota Takahashi2Hikari Iba3Shota Yamamoto4Takuya Watanabe5Kaori Kubota6Takehiro Kawashiri7Chise Taniguchi8Shutaro Katsurabayashi9Katsunori Iwasaki10Department of Pharmacy, Kyushu University Hospital, Fukuoka, 812-8582, Japan; Corresponding author. Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. Fax: +81 92 642 5937.Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, JapanDepartment of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, JapanDepartment of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, JapanDepartment of Lipid Signaling, National Center for Global Health and Medicine, Tokyo, 162-8655, JapanDepartment of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan; A.I.G. Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka, 814-0180, JapanDepartment of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan; A.I.G. Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka, 814-0180, JapanDepartment of Clinical Pharmacy and Pharmaceutical Care, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, JapanDepartment of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, JapanDepartment of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, JapanDepartment of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, 814-0180, Japan; A.I.G. Collaborative Research Institute for Aging and Brain Sciences, Fukuoka University, Fukuoka, 814-0180, JapanOxaliplatin is a key drug used in the management of solid tumors, such as colorectal cancer; however, it causes peripheral neuropathy. In this study, we investigated the effect of ibudilast, a phosphodiesterase inhibitor, on oxaliplatin-induced mechanical allodynia and histological changes in rats. Ibudilast (7.5 mg/kg, i.p., 5 times per week) reduced mechanical allodynia and histological changes induced by oxaliplatin (4 mg/kg, i.p., twice a week). In contrast, ibudilast (0.01–10 μM) had no effect on oxaliplatin-induced tumor cytotoxicity in murine colon adenocarcinoma 26 cells. These findings suggest that ibudilast could be useful for preventing oxaliplatin-induced peripheral neuropathy in clinical settings.http://www.sciencedirect.com/science/article/pii/S1347861321000608IbudilastOxaliplatinPeripheral neuropathy |
| spellingShingle | Nobuaki Egashira Yu Goto Ryota Takahashi Hikari Iba Shota Yamamoto Takuya Watanabe Kaori Kubota Takehiro Kawashiri Chise Taniguchi Shutaro Katsurabayashi Katsunori Iwasaki Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats Journal of Pharmacological Sciences Ibudilast Oxaliplatin Peripheral neuropathy |
| title | Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats |
| title_full | Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats |
| title_fullStr | Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats |
| title_full_unstemmed | Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats |
| title_short | Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats |
| title_sort | ibudilast suppresses oxaliplatin induced mechanical allodynia and neurodegeneration in rats |
| topic | Ibudilast Oxaliplatin Peripheral neuropathy |
| url | http://www.sciencedirect.com/science/article/pii/S1347861321000608 |
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