Quaternary Benzophenanthridine Alkaloids Act as Smac Mimetics and Overcome Resistance to Apoptosis

Quaternary Benzophenanthridine Alkaloids Act as Smac Mimetics and Overcome Resistance to Apoptosis

Defects in cell death signaling pathways are one of the hallmarks of cancer and can lead to resistance to conventional therapy. Natural products are promising compounds that can overcome this resistance. In the present study we studied the effect of six quaternary benzophenanthridine alkaloids (QBAs...

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Bibliographic Details
Main Authors:	Petra Kulíšková, Lucie Vašátková, Iva Slaninová
Format:	Article
Language:	English
Published:	MDPI AG 2023-10-01
Series:	International Journal of Molecular Sciences
Subjects:	apoptosis benzophenanthridine alkaloids cancer cell death cIAP Smac mimetic drug resistance
Online Access:	https://www.mdpi.com/1422-0067/24/20/15405

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