Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus
IntroductionChange in the composition of intestinal microbiota is associated with metabolic disorders such as gestational diabetes mellitus (GDM).MethodsTo understand how the microbiota impacts the development of gestational diabetes mellitus, we profiled the intestinal microbiome of 54 pregnant wom...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1175065/full |
| _version_ | 1827904666357202944 |
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| author | Xuejing Lyu Xuejing Lyu Shaona Wang Shaona Wang Jiaxin Zhong Lingzhu Cai Lingzhu Cai Yanhui Zheng Yanhui Zheng Ying Zhou Ying Zhou Ying Zhou Qionghua Chen Qionghua Chen Qiyuan Li Qiyuan Li |
| author_facet | Xuejing Lyu Xuejing Lyu Shaona Wang Shaona Wang Jiaxin Zhong Lingzhu Cai Lingzhu Cai Yanhui Zheng Yanhui Zheng Ying Zhou Ying Zhou Ying Zhou Qionghua Chen Qionghua Chen Qiyuan Li Qiyuan Li |
| author_sort | Xuejing Lyu |
| collection | DOAJ |
| description | IntroductionChange in the composition of intestinal microbiota is associated with metabolic disorders such as gestational diabetes mellitus (GDM).MethodsTo understand how the microbiota impacts the development of gestational diabetes mellitus, we profiled the intestinal microbiome of 54 pregnant women, including 27 GDM subjects, by employing 16S rRNA gene sequencing. Additionally, we conducted targeted metabolomics assays to validate the identified pathways with overrepresented metabolites.ResultsWe evaluated the patterns of changing abundances of operational taxonomic units (OTU) between GDM and the healthy counterparts over three timepoints. Based on the significant OTUs, we inferred 132 significantly altered metabolic pathways in GDM. And identified two overrepresented metabolites of pregnancy hormone, butyrate and mevalonate, as potential intermediary metabolites of intestinal microbiota in GDM. Finally, we validated the impacts of the intestinal microbiota on GDM by demonstrating consistent changes of the serum levels of progesterone, estradiol, butyrate, and mevalonate in an independent cohort.DiscussionOur findings confirm that alterations in the microbiota play a role in the development of GDM by impacting the metabolism of pregnancy hormones. This provides a novel perspective on the pathogenesis of GDM and introduces potential biomarkers that can be used for early diagnosis and prevention of the disease. |
| first_indexed | 2024-03-13T00:30:36Z |
| format | Article |
| id | doaj.art-0a7489a4bc78460bba724fb851551052 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-13T00:30:36Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-0a7489a4bc78460bba724fb8515510522023-07-10T12:53:23ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-07-011410.3389/fmicb.2023.11750651175065Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitusXuejing Lyu0Xuejing Lyu1Shaona Wang2Shaona Wang3Jiaxin Zhong4Lingzhu Cai5Lingzhu Cai6Yanhui Zheng7Yanhui Zheng8Ying Zhou9Ying Zhou10Ying Zhou11Qionghua Chen12Qionghua Chen13Qiyuan Li14Qiyuan Li15Clinical Medical Research Center for Obstetrics and Gynecology Diseases of Fujian Province, Laboratory of Research and Diagnosis of Gynecological Diseases of Xiamen City, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaSchool of Medicine, National Institute of Data Science in Health and Medicine, Xiamen University, Xiamen, ChinaThe Third Clinical Medical College, Fujian Medical University, Fuzhou, ChinaDepartment of Women’s Health, Xiamen Haicang District Maternity and Child Health Care Hospital, Xiamen, ChinaSchool of Medicine, National Institute of Data Science in Health and Medicine, Xiamen University, Xiamen, ChinaClinical Medical Research Center for Obstetrics and Gynecology Diseases of Fujian Province, Laboratory of Research and Diagnosis of Gynecological Diseases of Xiamen City, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaThe Third Clinical Medical College, Fujian Medical University, Fuzhou, ChinaClinical Medical Research Center for Obstetrics and Gynecology Diseases of Fujian Province, Laboratory of Research and Diagnosis of Gynecological Diseases of Xiamen City, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaThe Third Clinical Medical College, Fujian Medical University, Fuzhou, ChinaClinical Medical Research Center for Obstetrics and Gynecology Diseases of Fujian Province, Laboratory of Research and Diagnosis of Gynecological Diseases of Xiamen City, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaThe Third Clinical Medical College, Fujian Medical University, Fuzhou, ChinaSchool of Medicine, National Institute of Data Science in Health and Medicine, Xiamen University, Xiamen, ChinaClinical Medical Research Center for Obstetrics and Gynecology Diseases of Fujian Province, Laboratory of Research and Diagnosis of Gynecological Diseases of Xiamen City, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaThe Third Clinical Medical College, Fujian Medical University, Fuzhou, ChinaSchool of Medicine, National Institute of Data Science in Health and Medicine, Xiamen University, Xiamen, ChinaDepartment of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaIntroductionChange in the composition of intestinal microbiota is associated with metabolic disorders such as gestational diabetes mellitus (GDM).MethodsTo understand how the microbiota impacts the development of gestational diabetes mellitus, we profiled the intestinal microbiome of 54 pregnant women, including 27 GDM subjects, by employing 16S rRNA gene sequencing. Additionally, we conducted targeted metabolomics assays to validate the identified pathways with overrepresented metabolites.ResultsWe evaluated the patterns of changing abundances of operational taxonomic units (OTU) between GDM and the healthy counterparts over three timepoints. Based on the significant OTUs, we inferred 132 significantly altered metabolic pathways in GDM. And identified two overrepresented metabolites of pregnancy hormone, butyrate and mevalonate, as potential intermediary metabolites of intestinal microbiota in GDM. Finally, we validated the impacts of the intestinal microbiota on GDM by demonstrating consistent changes of the serum levels of progesterone, estradiol, butyrate, and mevalonate in an independent cohort.DiscussionOur findings confirm that alterations in the microbiota play a role in the development of GDM by impacting the metabolism of pregnancy hormones. This provides a novel perspective on the pathogenesis of GDM and introduces potential biomarkers that can be used for early diagnosis and prevention of the disease.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1175065/fullgestational diabetes mellitusgut microbiotahormone metabolismtime seriesmetabolic biomarker |
| spellingShingle | Xuejing Lyu Xuejing Lyu Shaona Wang Shaona Wang Jiaxin Zhong Lingzhu Cai Lingzhu Cai Yanhui Zheng Yanhui Zheng Ying Zhou Ying Zhou Ying Zhou Qionghua Chen Qionghua Chen Qiyuan Li Qiyuan Li Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus Frontiers in Microbiology gestational diabetes mellitus gut microbiota hormone metabolism time series metabolic biomarker |
| title | Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus |
| title_full | Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus |
| title_fullStr | Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus |
| title_full_unstemmed | Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus |
| title_short | Gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus |
| title_sort | gut microbiome interacts with pregnancy hormone metabolites in gestational diabetes mellitus |
| topic | gestational diabetes mellitus gut microbiota hormone metabolism time series metabolic biomarker |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1175065/full |
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