Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods
Benzodiazepines (BDZs) are used in clinics for anxiolysis, anticonvulsants, sedative hypnosis, and muscle relaxation. They have high consumptions worldwide because of their easy availability and potential addiction. They are often used for suicide or criminal practices such as abduction and drug-fac...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Journal of Pharmaceutical Analysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177923000588 |
| _version_ | 1797812071293779968 |
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| author | Yi-Xin Zhang Yuan Zhang Yu Bian Ya-Jie Liu Ai Ren Yu Zhou Du Shi Xue-Song Feng |
| author_facet | Yi-Xin Zhang Yuan Zhang Yu Bian Ya-Jie Liu Ai Ren Yu Zhou Du Shi Xue-Song Feng |
| author_sort | Yi-Xin Zhang |
| collection | DOAJ |
| description | Benzodiazepines (BDZs) are used in clinics for anxiolysis, anticonvulsants, sedative hypnosis, and muscle relaxation. They have high consumptions worldwide because of their easy availability and potential addiction. They are often used for suicide or criminal practices such as abduction and drug-facilitated sexual assault. The pharmacological effects of using small doses of BDZs and their detections from complex biological matrices are challenging. Efficient pretreatment methods followed by accurate and sensitive detections are necessary. Herein, pretreatment methods for the extraction, enrichment, and preconcentration of BDZs as well as the strategies for their screening, identification, and quantitation developed in the past five years have been reviewed. Moreover, recent advances in various methods are summarized. Characteristics and advantages of each method are encompassed. Future directions of the pretreatment and detection methods for BDZs are also reviewed. |
| first_indexed | 2024-03-13T07:32:09Z |
| format | Article |
| id | doaj.art-0a7a83945b96424189f65531f471df3a |
| institution | Directory Open Access Journal |
| issn | 2095-1779 |
| language | English |
| last_indexed | 2024-03-13T07:32:09Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj.art-0a7a83945b96424189f65531f471df3a2023-06-04T04:23:38ZengElsevierJournal of Pharmaceutical Analysis2095-17792023-05-01135442462Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methodsYi-Xin Zhang0Yuan Zhang1Yu Bian2Ya-Jie Liu3Ai Ren4Yu Zhou5Du Shi6Xue-Song Feng7School of Pharmacy, China Medical University, Shenyang, 110122, ChinaSchool of Pharmacy, China Medical University, Shenyang, 110122, ChinaSchool of Pharmacy, China Medical University, Shenyang, 110122, ChinaSchool of Pharmacy, China Medical University, Shenyang, 110122, ChinaSchool of Pharmacy, China Medical University, Shenyang, 110122, ChinaDepartment of Pharmacy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, ChinaDepartment of Urology, The First Hospital of China Medical University, Shenyang, 110001, China; Corresponding author.School of Pharmacy, China Medical University, Shenyang, 110122, China; Corresponding author.Benzodiazepines (BDZs) are used in clinics for anxiolysis, anticonvulsants, sedative hypnosis, and muscle relaxation. They have high consumptions worldwide because of their easy availability and potential addiction. They are often used for suicide or criminal practices such as abduction and drug-facilitated sexual assault. The pharmacological effects of using small doses of BDZs and their detections from complex biological matrices are challenging. Efficient pretreatment methods followed by accurate and sensitive detections are necessary. Herein, pretreatment methods for the extraction, enrichment, and preconcentration of BDZs as well as the strategies for their screening, identification, and quantitation developed in the past five years have been reviewed. Moreover, recent advances in various methods are summarized. Characteristics and advantages of each method are encompassed. Future directions of the pretreatment and detection methods for BDZs are also reviewed.http://www.sciencedirect.com/science/article/pii/S2095177923000588BenzodiazepineBiological matricesDetection methodsSample preparation |
| spellingShingle | Yi-Xin Zhang Yuan Zhang Yu Bian Ya-Jie Liu Ai Ren Yu Zhou Du Shi Xue-Song Feng Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods Journal of Pharmaceutical Analysis Benzodiazepine Biological matrices Detection methods Sample preparation |
| title | Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods |
| title_full | Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods |
| title_fullStr | Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods |
| title_full_unstemmed | Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods |
| title_short | Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods |
| title_sort | benzodiazepines in complex biological matrices recent updates on pretreatment and detection methods |
| topic | Benzodiazepine Biological matrices Detection methods Sample preparation |
| url | http://www.sciencedirect.com/science/article/pii/S2095177923000588 |
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