Quantitative systems pharmacology modeling provides insight into inter‐mouse variability of Anti‐CTLA4 response

Abstract Clinical responses of immuno‐oncology therapies are highly variable among patients. Similar response variability has been observed in syngeneic mouse models. Understanding of the variability in the mouse models may shed light on patient variability. Using a murine anti‐CTLA4 antibody as a c...

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Bibliographic Details
Main Authors: Wenlian Qiao, Lin Lin, Carissa Young, Jatin Narula, Fei Hua, Andrew Matteson, Andrea Hooper, Lore Gruenbaum, Alison Betts
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.12800