Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6
Prostate cancer (PCa) is one of the most common malignancies in Western countries. Studies have shown that androgen contributes to the progression of PCa, but how androgen promotes PCa remains largely unknown. Here, we demonstrated that androgen suppressed the expression of miR-760 depending on the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Asian Journal of Andrology |
| Subjects: | |
| Online Access: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2021;volume=23;issue=1;spage=85;epage=90;aulast= |
| _version_ | 1818675526577946624 |
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| author | Shuo Wang Yong Yang Yu-Dong Cao Xing-Xing Tang Peng Du |
| author_facet | Shuo Wang Yong Yang Yu-Dong Cao Xing-Xing Tang Peng Du |
| author_sort | Shuo Wang |
| collection | DOAJ |
| description | Prostate cancer (PCa) is one of the most common malignancies in Western countries. Studies have shown that androgen contributes to the progression of PCa, but how androgen promotes PCa remains largely unknown. Here, we demonstrated that androgen suppressed the expression of miR-760 depending on the interaction between androgen and androgen receptor (AR). miR-760 was downregulated in prostate cancer tissues compared with normal tissues. Functional experiments showed that miR-760 downregulation promoted the proliferation and growth of LNCaP and 22rv1 cells. In contrast, miR-760 ectopic expression inhibited the proliferation of LNCaP and 22rv1 cells. DNA synthesis was suppressed by miR-760. Mechanistically, miR-760 bound to the 3'UTR of interleukin 6 (IL6 ). A mutation in the binding site disrupted their interaction. In addition, silencing ofIL 6 suppressed the proliferation of LNCaP and 22rv1 cells. IL6 was upregulated in PCa tissues. Our study reveals that androgen downregulates miR-760 to promote the growth of PCa cells by regulating IL6. |
| first_indexed | 2024-12-17T08:28:59Z |
| format | Article |
| id | doaj.art-0a7b9128439645009814ee2cc7e2091b |
| institution | Directory Open Access Journal |
| issn | 1008-682X 1745-7262 |
| language | English |
| last_indexed | 2024-12-17T08:28:59Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj.art-0a7b9128439645009814ee2cc7e2091b2022-12-21T21:56:39ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622021-01-01231859010.4103/aja.aja_20_20Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6Shuo WangYong YangYu-Dong CaoXing-Xing TangPeng DuProstate cancer (PCa) is one of the most common malignancies in Western countries. Studies have shown that androgen contributes to the progression of PCa, but how androgen promotes PCa remains largely unknown. Here, we demonstrated that androgen suppressed the expression of miR-760 depending on the interaction between androgen and androgen receptor (AR). miR-760 was downregulated in prostate cancer tissues compared with normal tissues. Functional experiments showed that miR-760 downregulation promoted the proliferation and growth of LNCaP and 22rv1 cells. In contrast, miR-760 ectopic expression inhibited the proliferation of LNCaP and 22rv1 cells. DNA synthesis was suppressed by miR-760. Mechanistically, miR-760 bound to the 3'UTR of interleukin 6 (IL6 ). A mutation in the binding site disrupted their interaction. In addition, silencing ofIL 6 suppressed the proliferation of LNCaP and 22rv1 cells. IL6 was upregulated in PCa tissues. Our study reveals that androgen downregulates miR-760 to promote the growth of PCa cells by regulating IL6.http://www.ajandrology.com/article.asp?issn=1008-682X;year=2021;volume=23;issue=1;spage=85;epage=90;aulast=androgen; interleukin 6; mir-760; prostate cancer |
| spellingShingle | Shuo Wang Yong Yang Yu-Dong Cao Xing-Xing Tang Peng Du Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6 Asian Journal of Andrology androgen; interleukin 6; mir-760; prostate cancer |
| title | Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6 |
| title_full | Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6 |
| title_fullStr | Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6 |
| title_full_unstemmed | Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6 |
| title_short | Androgen downregulation of miR-760 promotes prostate cancer cell growth by regulating IL6 |
| title_sort | androgen downregulation of mir 760 promotes prostate cancer cell growth by regulating il6 |
| topic | androgen; interleukin 6; mir-760; prostate cancer |
| url | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2021;volume=23;issue=1;spage=85;epage=90;aulast= |
| work_keys_str_mv | AT shuowang androgendownregulationofmir760promotesprostatecancercellgrowthbyregulatingil6 AT yongyang androgendownregulationofmir760promotesprostatecancercellgrowthbyregulatingil6 AT yudongcao androgendownregulationofmir760promotesprostatecancercellgrowthbyregulatingil6 AT xingxingtang androgendownregulationofmir760promotesprostatecancercellgrowthbyregulatingil6 AT pengdu androgendownregulationofmir760promotesprostatecancercellgrowthbyregulatingil6 |